For faster navigation, this Iframe is preloading the Wikiwand page for 羟嗪.

羟嗪

此条目可参照英语维基百科相应条目来扩充。 (2023年9月23日)若您熟悉来源语言和主题,请协助参考外语维基百科扩充条目。请勿直接提交机械翻译,也不要翻译不可靠、低品质内容。依版权协议,译文需在编辑摘要注明来源,或于讨论页顶部标记((Translated page))标签。
羟嗪
临床资料
商品名英语Drug nomenclature安泰乐(Atarax)
AHFS/Drugs.comMonograph
MedlinePlusa682866
怀孕分级
  • : A
给药途径口服, 肌肉注射
ATC码
法律规范状态
法律规范
药物动力学数据
生物利用度High in-vivo
血浆蛋白结合率93%
药物代谢肝脏
生物半衰期20–24 小时[1]
排泄途径尿液, 粪便
识别信息
  • (±)-2-(2-{4-[(4-chlorophenyl)-phenylmethyl]piperazin-1-yl}ethoxy)ethanol
CAS号68-88-2  checkY
PubChem CID
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
CompTox Dashboard英语CompTox Chemicals Dashboard (EPA)
ECHA InfoCard100.000.630 编辑维基数据链接
化学信息
化学式C21H27ClN2O2
摩尔质量374.904 g/mol
3D模型(JSmol英语JSmol
  • Clc1ccc(cc1)C(c2ccccc2)N3CCN(CC3)CCOCCO
  • InChI=1S/C21H27ClN2O2/c22-20-8-6-19(7-9-20)21(18-4-2-1-3-5-18)24-12-10-23(11-13-24)14-16-26-17-15-25/h1-9,21,25H,10-17H2 checkY
  • Key:ZQDWXGKKHFNSQK-UHFFFAOYSA-N checkY

qiǎngqín(英语:hydroxyzine,药品名:安泰乐维泰宁(Vistaril, hydroxyzine pamoate, capsule 25mg F631-15)、Atarax)是属于二苯甲烷哌嗪类的第一代抗组胺药。由于其可以与某些大脑中的受体结合,它被用作强力的抗焦虑药与轻度的抗强迫症药,用来治疗精神上的焦虑与紧张。[2]由于其有抗组胺的效果,也可治疗严重的瘙痒痛觉过敏晕车引起的恶心,甚至作为缓解阿片戒断反应英语Opioid withdrawal的药物。[3][4]

注释

  1. ^ Simons FE, Simons KJ, Frith EM. The pharmacokinetics and antihistaminic of the H1 receptor antagonist hydroxyzine. The Journal of Allergy and Clinical Immunology. January 1984, 73 (1 Pt 1): 69–75. PMID 6141198. doi:10.1016/0091-6749(84)90486-x. 
  2. ^ SCHRAM, WS. Use of hydroxyzine in psychosis.. Diseases of the Nervous System. March 1959, 20 (3): 126–9. PMID 13639831. 
  3. ^ FDA DrugInfo: http://dailymed.nlm.nih.gov/dailymed/archives/fdaDrugInfo.cfm?archiveid=51459页面存档备份,存于互联网档案馆
  4. ^ Hydroxyzine Facts and Comparisons at Drugs.com. (原始内容存档于2015-07-02). 

参见

  • 双羟萘酸英语Pamoic acid(pamoate;帕莫酸;扑酸)

外部链接

Template:Dopamine receptor modulators英语Template:Dopamine receptor modulators

Template:Serotonergics (( Template:SafeTemplate ))

{{bottomLinkPreText}} {{bottomLinkText}}
羟嗪
Listen to this article

This browser is not supported by Wikiwand :(
Wikiwand requires a browser with modern capabilities in order to provide you with the best reading experience.
Please download and use one of the following browsers:

This article was just edited, click to reload
This article has been deleted on Wikipedia (Why?)

Back to homepage

Please click Add in the dialog above
Please click Allow in the top-left corner,
then click Install Now in the dialog
Please click Open in the download dialog,
then click Install
Please click the "Downloads" icon in the Safari toolbar, open the first download in the list,
then click Install
{{::$root.activation.text}}

Install Wikiwand

Install on Chrome Install on Firefox
Don't forget to rate us

Tell your friends about Wikiwand!

Gmail Facebook Twitter Link

Enjoying Wikiwand?

Tell your friends and spread the love:
Share on Gmail Share on Facebook Share on Twitter Share on Buffer

Our magic isn't perfect

You can help our automatic cover photo selection by reporting an unsuitable photo.

This photo is visually disturbing This photo is not a good choice

Thank you for helping!


Your input will affect cover photo selection, along with input from other users.

X

Get ready for Wikiwand 2.0 🎉! the new version arrives on September 1st! Don't want to wait?