戊二酰亚胺
| 戊二酰亚胺 | |
|---|---|
| |
| |
| IUPAC名 Piperidine-2,6-dione 哌啶-2,6-二酮 | |
| 别名 | 2,6-Diketopiperidine |
| 识别 | |
| CAS号 | 1121-89-7 
|
| PubChem | 70726 |
| ChemSpider | 63891 |
| SMILES |
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| 性质 | |
| 化学式 | C5H7NO2 |
| 摩尔质量 | 113.11 g/mol g·mol⁻¹ |
| 熔点 | 155-157 °C[1] |
| 若非注明，所有数据均出自标准状态（25 ℃，100 kPa）下。 | |
戊二酰亚胺是一种有机化合物，结构简式为(CH2)3(CO)2NH。它是一种白色固体，该化合物在戊二酸酰胺脱水后形成[2]。
戊二酰亚胺有时称作2,6-哌啶二酮。它是多种药物的核心，包括沙利度胺，一种用于治疗多发性骨髓瘤[3]和麻风病的药物[4]；和放线菌酮，一种有效的蛋白质合成抑制剂[5]。
参考文献
- ^ Glutarimide - Sigma-Aldrich
- ^ Paris, G.; Berlinguet, L.; Gaudry, R.; English, Jr., J.; Dayan, J. E. Glutaric Acid and Glutarimide. Organic Syntheses. 1957, 37: 47. doi:10.15227/orgsyn.037.0047.
- ^ A to Z List of Cancer Drugs: Thalidomide. National Cancer Institute. [20 September 2021]. （原始内容存档于2022-08-15）.
- ^ Stolberg, Sheryl Gay. Thalidomide Approved to Treat Leprosy, With Other Uses Seen. New York Times. 17 July 1998 [20 September 2021]. （原始内容存档于2020-12-03）.
- ^ Hugh D. Sisler, Malcolm R. Siegel; Cycloheximide and Other Glutarimide Antibiotics （页面存档备份，存于互联网档案馆）; Mechanism of Action pp 283-307
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