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溴替唑仑

溴替唑仑
临床资料
商品名英语Drug nomenclatureLendormin
其他名称溴噻二氮䓬
AHFS/Drugs.com国际药品名称
给药途径Oral
ATC码
法律规范状态
法律规范
  • Schedule IV
  • Prescription only (Anlage III for higher doses)
  • Class C
  • 未列入管制[1]
药物动力学数据
生物利用度48–95%
药物代谢Hepatic
生物半衰期4.4 hours (range, 2.6–6.9 h)
排泄途径Renal
识别信息
  • 2-Bromo-4-(2-chlorophenyl)-9-methyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine
CAS号57801-81-7  checkY
PubChem CID
DrugBank
ChemSpider
UNII
KEGG
ChEMBL
CompTox Dashboard英语CompTox Chemicals Dashboard (EPA)
ECHA InfoCard100.055.404 编辑维基数据链接
化学信息
化学式C15H10BrClN4S
摩尔质量393.69 g·mol−1
3D模型(JSmol英语JSmol
  • ClC1=CC=CC=C1C2=NCC3=NN=C(C)N3C4=C2C=C(Br)S4
  • InChI=1S/C15H10BrClN4S/c1-8-19-20-13-7-18-14(9-4-2-3-5-11(9)17)10-6-12(16)22-15(10)21(8)13/h2-6H,7H2,1H3 checkY
  • Key:UMSGKTJDUHERQW-UHFFFAOYSA-N checkY

溴替唑仑是一种有机化合物,化学式为C15H10BrClN4S,是一种噻吩并三氮唑并二氮䓬类[2]镇静安眠药[3]。在中国,它被列作第二类精神药品受到管控;[4]它在美国英国加拿大被禁售。

它在盐酸中加热水解,得到2-甲基三唑基甲氨基-3-(2-氯苯甲酰基)-5-溴噻吩。[5]

参考文献

  1. ^ DEA Diversion Control Division (PDF). [2022-12-12]. (原始内容 (PDF)存档于2019-10-17). 
  2. ^ Catabay A, Taniguchi M, Jinno K, Pesek JJ, Williamsen E. Separation of 1,4-Benzodiazepines and Analogues Using Cholesteryl-10-Undecenoate Bonded Phase in Microcolumn Liquid Chromatography. Journal of Chromatographic Science. 1 March 1998, 36 (3): 113. doi:10.1093/chromsci/36.3.111可免费查阅. 
  3. ^ Fink M, Irwin P. Pharmacoelectroencephalographic study of brotizolam, a novel hypnotic. Clinical Pharmacology and Therapeutics. September 1981, 30 (3): 336–42. PMID 7273596. S2CID 30788171. doi:10.1038/clpt.1981.169. 
  4. ^ 麻醉药品品种目录 精神药品品种目录(2013版). 宁夏回族自治区药品监督管理局. 2019-05-06 [2022-12-12]. (原始内容存档于2022-12-12). 
  5. ^ Yoshinori Sugimoto, Aya Kugimiya, Yoshifumi Yoshimura, Hideo Naoki. Structural elucidation of novel degradation product of brotizolam. Bioorganic & Medicinal Chemistry Letters. 2013-06, 23 (12): 3515–3518 [2022-12-12]. doi:10.1016/j.bmcl.2013.04.044. (原始内容存档于2018-06-28) (英语). 

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溴替唑仑
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