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三环类抗抑郁药

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第一种上市的抗抑郁药丙咪嗪,其化学结构有三个

三环类抗抑郁药(英语:Tricyclic antidepressants (TCA))是一类以化学结构命名的药物,主要用作抗抑郁药。TCA最早于1950年发现,于1950年代见于市场。[1]带有四个环的四环类抗抑郁药(TeCA)与此类药物密切相关。

医生有时仍会开出TCA处方治疗抑郁症状,不过这类药物在世界上大部分地区都已被选择性5-羟色胺再摄取抑制剂(SSRI)、5-羟色胺和去甲肾上腺素再摄取抑制剂(SNRI)及去甲肾上腺素再摄取抑制剂(NRI)替代。SSRI与TCA的不良反应强度相似。[2]

阿米替林是现今使用最广泛的TCA类药物。

参考资料

  1. ^ Carson VB (2000). Mental health nursing: the nurse-patient journey页面存档备份,存于互联网档案馆) W.B. Saunders. ISBN 978-0-7216-8053-8. pp. 423
  2. ^ Trindade, E.; Menon, D.; Topfer, L. A.; Coloma, C. Adverse effects associated with selective serotonin reuptake inhibitors and tricyclic antidepressants: a meta-analysis. Canadian Medical Association Journal. November 1998, 159 (10): 1245–1252 [2016-09-25]. PMC 1229819可免费查阅. PMID 9861221. (原始内容存档于2017-02-22). 
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三环类抗抑郁药
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