多塞平
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| 临床资料 | |
|---|---|
| 商品名 | Sinequan, Quitaxon, Adapin, Triadapin, Aponal, others |
| 其他名称 | NSC-108160 |
| AHFS/Drugs.com | Monograph |
| MedlinePlus | a682390 |
| 核准状况 | |
| 怀孕分级 |
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| 给药途径 | By mouth, topical, intravenous, intramuscular injection[1] |
| 药物类别 | 三环类抗抑郁药（TCA） |
| ATC码 | |
| 法律规范状态 | |
| 法律规范 |
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| 药物动力学数据 | |
| 生物利用度 | 13–45% (mean 29%)[2] |
| 血浆蛋白结合率 | 76% |
| 药物代谢 | Hepatic (CYP2D6, CYP2C19)[2] |
| 代谢产物 | Nordoxepin, glucuronide conjugates |
| 生物半衰期 | Doxepin: 8–24 hours (mean 17 hours) Nordoxepin: 28–31 hours |
| 排泄途径 | Urine: ~50%[2] Feces: minor[2] |
| 识别信息 | |
| |
| CAS号 | 1668-19-5（ 1229-29-4 (hydrochloride) 3607-18-9 (cidoxepin)）  |
| PubChem CID | |
| IUPHAR/BPS | |
| DrugBank | |
| ChemSpider | |
| UNII | |
| KEGG | |
| ChEBI | |
| ChEMBL | |
| PDB配体ID | |
| CompTox Dashboard (EPA) | |
| 化学信息 | |
| 化学式 | C19H21NO |
| 摩尔质量 | 279.38 g·mol−1 |
| 3D模型（JSmol） | |
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参考文献
- ^ Doxepin Hydrochloride. Martindale: The Complete Drug Reference. London, UK: Pharmaceutical Press. 30 January 2013 [3 December 2013].
- ^ 2.0 2.1 2.2 2.3 Lemke TL, Williams DA. Antidepressants. Foye's Principles of Medicinal Chemistry. Lippincott Williams & Wilkins. 24 January 2012: 604–. ISBN 978-1-60913-345-0.
- ^ Anvisa. RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial [Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control]. Diário Oficial da União. 2023-03-31 (2023-04-04) [2023-08-16]. （原始内容存档于2023-08-03） （巴西葡萄牙语）.
- ^ Doxepin Hydrochloride. Drugs.com. American Society of Health-System Pharmacists. [20 March 2019].
- ^ Silenor (doxepin) label (PDF). FDA. 17 March 2010 [25 October 2017]. For label updates see FDA index page for NDA 022036
外部链接
- Doxepin. Drug Information Portal. U.S. National Library of Medicine.
- Doxepin hydrochloride. Drug Information Portal. U.S. National Library of Medicine.
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