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去甲肾上腺素-多巴胺再吸收抑制剂

去甲肾上腺素键线式结构
多巴胺键线式结构

去甲肾上腺素-多巴胺再吸收抑制剂NDRI)是一种借由阻挡多巴胺转运体(DAT)及去甲肾上腺素转运体(NET)而达成作用的再吸收抑制剂[1] 它可使细胞膜外的多巴胺去甲肾上腺素浓度增加,达到更多神经传导英语neurotransmission[1]

用途

去甲肾上腺素-多巴胺再吸收抑制剂用于抑郁症, ADHD[2], 猝睡症的治疗,以及作为抗帕金森制剂英语Antiparkinson.

NDRI 清单

哌甲酯键线式

此处仅列出对多巴胺转运体(DAT)及去甲肾上腺素转运体(NET)选择性相对于血清素转运体(SERT)较高的化合物,对三种转运器都有抑制作用的参见:三重再摄取抑制剂

参见

参考文献

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去甲肾上腺素-多巴胺再吸收抑制剂
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