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Image illustrative de l’article Topotécan
Nom UICPA (S)-10-[(diméthylamino)méthyl]-4-éthyl-4,9-
No ECHA 100.213.372
Code ATC L01XX17
DrugBank APRD00687
PubChem 6419854
Propriétés chimiques
Formule C23H23N3O5  [Isomères]
Masse molaire[1] 421,445 8 ± 0,022 1 g/mol
C 65,55 %, H 5,5 %, N 9,97 %, O 18,98 %,
Données pharmacocinétiques
Biodisponibilité NA
Liaison protéique 35 %
Métabolisme hépatique
Demi-vie d’élim. 2-3 heures


Unités du SI et CNTP, sauf indication contraire.

Le topotécan est un anticancéreux, antinéoplasique et antimitotique. Il fait partie de la classe des camptothécines.

Mode d'action

Le topotécan agit en se liant à l'ADN topoisomérase I et l'inhibe.



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