For faster navigation, this Iframe is preloading the Wikiwand page for Nélarabine.


Image illustrative de l’article Nélarabine
Structure de la nélarabine
Nom UICPA 9-(β-D-arabinofuranosyl)-6-méthoxy-9H-purin-2-amine
No ECHA 100.170.768
Code ATC L01BB07
DrugBank DB01280
PubChem 3011155
ChEBI 63612
Propriétés chimiques
Formule C11H15N5O5  [Isomères]
Masse molaire[1] 297,267 3 ± 0,012 4 g/mol
C 44,44 %, H 5,09 %, N 23,56 %, O 26,91 %,

Unités du SI et CNTP, sauf indication contraire.

La nélarabine est un nucléoside analogue à une purine utilisée en chimiothérapie contre certaines leucémies rares affectant les lymphocytes T[2]. Elle est constituée de 6-O-méthylguanine, une base azotée dérivée de la guanine, et de β-D-arabinofuranose remplaçant le β-D-ribofuranose de la guanosine. Elle est convertie in vivo en arabinosylguanine nucléotide triphosphate (araGTP)[3] qui inhibe la synthèse de l'ADN et est donc responsable de la cytotoxicité de la molécule.

Notes et références

  1. Masse molaire calculée d’après « Atomic weights of the elements 2007 », sur
  2. (en) Martin H. Cohen, John R. Johnson, Robert Justice et Richard Pazdur, « FDA Drug Approval Summary: Nelarabine (Arranon®) for the Treatment of T-Cell Lymphoblastic Leukemia/Lymphoma », The Oncologist, vol. 13, no 6,‎ , p. 709-714 (PMID 18586926, DOI 10.1634/theoncologist.2006-0017, lire en ligne)
  3. (en) Mark Sanford et Katherine A. Lyseng-Williamson, « Nelarabine », Drugs, vol. 68, no 4,‎ , p. 439-447 (PMID 18318562, DOI 10.2165/00003495-200868040-00004, lire en ligne)
{{bottomLinkPreText}} {{bottomLinkText}}
Listen to this article

This browser is not supported by Wikiwand :(
Wikiwand requires a browser with modern capabilities in order to provide you with the best reading experience.
Please download and use one of the following browsers:

This article was just edited, click to reload
This article has been deleted on Wikipedia (Why?)

Back to homepage

Please click Add in the dialog above
Please click Allow in the top-left corner,
then click Install Now in the dialog
Please click Open in the download dialog,
then click Install
Please click the "Downloads" icon in the Safari toolbar, open the first download in the list,
then click Install

Install Wikiwand

Install on Chrome Install on Firefox
Don't forget to rate us

Tell your friends about Wikiwand!

Gmail Facebook Twitter Link

Enjoying Wikiwand?

Tell your friends and spread the love:
Share on Gmail Share on Facebook Share on Twitter Share on Buffer

Our magic isn't perfect

You can help our automatic cover photo selection by reporting an unsuitable photo.

This photo is visually disturbing This photo is not a good choice

Thank you for helping!

Your input will affect cover photo selection, along with input from other users.


Get ready for Wikiwand 2.0 🎉! the new version arrives on September 1st! Don't want to wait?