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Thymidylate synthase

La thymidylate synthase (TS) est une enzyme impliquée dans la voie de biosynthèse de la thymidine, elle est donc essentielle à la synthèse de l'ADN à laquelle elle fournit l'un de ses précurseurs. Elle catalyse la formation de TMP par méthylation du dUMP. Le donneur de méthyle est le 5,10-méthylènetétrahydrofolate.

La thymidylate synthase est utilisée pour préciser la classification taxinomique de certaines espèces, selon qu'elle est ou non fusionnée avec la dihydrofolate réductase.

Elle est prise comme cible par certains inhibiteurs pharmocologiques: le méthotrexate polyglutamates et le FH2Glun.

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Thymidylate synthase
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