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Dabrafenib

Le Dabrafenib est une molécule développée comme médicament, inhibiteur de la MAPK (mitogen-activated protein kinase). Ce médicament est commercialisé en France par Novartis sous le nom de spécialité Tafinlar sous forme de gélules dosées à 50 et 75 mg. Il a bénéficié d'une autorisation de mise sur le marché attribué par l'agence européenne du médicament en 2013 [1],[2]

Utilisation

Il améliore la survie du mélanome malin métastatique porteur de la mutation BRAF-V600 . la réponse serait meilleure s'il est utilisé en combinaison avec le Trametinib[3],[4], en particulier en matière de durée de survie[5],[6] .

Notes et références

  1. « Autorisation - Minigraphie », sur sante.fr (consulté le ).
  2. (en) « European Medicines Agency recommends approval of Tafinlar for the treatment metastatic melanoma - », sur European Medicines Agency, (consulté le ).
  3. (en) Hauschild A, Grob JJ, Demidov LV et al. Dabrafenib in BRAF-mutated metastatic melanoma: a multicentre, open-label, phase 3 randomised controlled trial, Lancet, 2012;380:358-365
  4. (en) Flaherty KT, Infante JR, Daud A et al. Combined BRAF and MEK Inhibition in melanoma with BRAF V600 mutations, N Engl J Med, 2012;367:1694-1703
  5. (en) Robert C, Karaszewska B, Schachter J et al. Improved overall survival in melanoma with combined dabrafenib and trametinib, N Engl J Med, 2015;372:30-39.
  6. (en) Reinhard Dummer et al. « Five-Year Analysis of Adjuvant Dabrafenib plus Trametinib in Stage III Melanoma » N Engl J Med. 2020 Sep 17;383(12):1139-1148. DOI 10.1056/NEJMoa2005493.
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Dabrafenib
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