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Ifosfamide

Ifosfamide
Image illustrative de l’article Ifosfamide
Identification
Nom UICPA N-3-bis(2-chloroéthyl)-1,3,2-oxazaphosphinan-2-amide-2-oxyde
Synonymes

3-(2-chloréthyl)-2-[(2-chloréthyl)amino]tétrahydro-2H-1,3,2-oxazaphosphorine 2-oxyde

No CAS
No ECHA 100.021.126
No CE 223-237-3
Code ATC L01AA06
DrugBank APRD00007
PubChem 3690
SMILES
InChI
Propriétés chimiques
Formule C7H15Cl2N2O2P  [Isomères]
Masse molaire[1] 261,086 ± 0,012 g/mol
C 32,2 %, H 5,79 %, Cl 27,16 %, N 10,73 %, O 12,26 %, P 11,86 %,
Propriétés physiques
fusion 39 à 41 °C [2]
Écotoxicologie
LogP 0,86 [2]
Données pharmacocinétiques
Biodisponibilité 100 %
Métabolisme hépatique
Demi-vie d’élim. 60-80 % en 72 heures
Excrétion

rénal

Considérations thérapeutiques
Voie d’administration intraveineuse

Unités du SI et CNTP, sauf indication contraire.

L'ifosfamide est un anticancéreux alkylant.

Il fait partie de la liste des médicaments essentiels de l'Organisation mondiale de la santé (liste mise à jour en )[3].

Notes et références

  1. Masse molaire calculée d’après « Atomic weights of the elements 2007 », sur www.chem.qmul.ac.uk.
  2. a et b (en) « Ifosfamide », sur ChemIDplus, consulté le 14 mai 2010
  3. WHO Model List of Essential Medicines, 18th list, avril 2013
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Ifosfamide
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