TPM4

TPM4
Identifiers
Aliases	TPM4, HEL-S-108, tropomyosin 4
External IDs	OMIM: 600317; MGI: 2449202; HomoloGene: 100849; GeneCards: TPM4; OMA:TPM4 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	16,103,002 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	72,906,986 bp
RNA expression pattern
	Top expressed in
	tendon of biceps brachii; ; stromal cell of endometrium; ; right coronary artery; ; gallbladder; ; ascending aorta; ; body of uterus; ; left uterine tube; ; smooth muscle tissue; ; Descending thoracic aorta; ; tibial arteries;
	Top expressed in
	genital tubercle; ; tail of embryo; ; belly cord; ; left lung lobe; ; mandibular prominence; ; maxillary prominence; ; dermis; ; endothelial cell of lymphatic vessel; ; vas deferens; ; abdominal wall;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	calcium ion binding; actin binding; structural constituent of muscle; protein binding; metal ion binding; identical protein binding; protein homodimerization activity; protein heterodimerization activity; actin filament binding;
Cellular component	cytoplasm; filamentous actin; podosome; cytosol; muscle thin filament tropomyosin; cortical cytoskeleton; extracellular exosome; cytoskeleton; membrane; stress fiber; focal adhesion; actin filament; actin cytoskeleton;
Biological process	osteoblast differentiation; muscle filament sliding; muscle contraction; actin filament organization;
	Sources:Amigo / QuickGO
Orthologs
	7171
	326618
	ENSG00000167460
	ENSMUSG00000031799
	P67936
	Q6IRU2
	NM_001145160; NM_003290; NM_001367836; NM_001367837; NM_001367838
	NM_001001491
	NP_001138632; NP_003281; NP_001354765; NP_001354766; NP_001354767
	NP_001001491
	Wikidata
View/Edit Human	View/Edit Mouse

Tropomyosin alpha-4 chain is a protein that in humans is encoded by the TPM4 gene.^[5]^[6]

References

Rasmussen HH, van Damme J, Puype M, et al. (1993). "Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes". Electrophoresis. 13 (12): 960–9. doi:10.1002/elps.11501301199. PMID 1286667. S2CID 41855774.
MacLeod AR, Talbot K, Smillie LB, Houlker C (1987). "Characterization of a cDNA defining a gene family encoding TM30p1, a human fibroblast tropomyosin". J. Mol. Biol. 194 (1): 1–10. doi:10.1016/0022-2836(87)90710-8. PMID 3612796.
MacLeod AR, Houlker C, Reinach FC, et al. (1986). "A muscle-type tropomyosin in human fibroblasts: evidence for expression by an alternative RNA splicing mechanism". Proc. Natl. Acad. Sci. U.S.A. 82 (23): 7835–9. doi:10.1073/pnas.82.23.7835. PMC 390864. PMID 3865200.
Lawrence B, Perez-Atayde A, Hibbard MK, et al. (2000). "TPM3-ALK and TPM4-ALK oncogenes in inflammatory myofibroblastic tumors". Am. J. Pathol. 157 (2): 377–84. doi:10.1016/S0002-9440(10)64550-6. PMC 1850130. PMID 10934142.
Meech SJ, McGavran L, Odom LF, et al. (2001). "Unusual childhood extramedullary hematologic malignancy with natural killer cell properties that contains tropomyosin 4--anaplastic lymphoma kinase gene fusion". Blood. 98 (4): 1209–16. doi:10.1182/blood.V98.4.1209. PMID 11493472.
Yi J, Kloeker S, Jensen CC, et al. (2002). "Members of the Zyxin family of LIM proteins interact with members of the p130Cas family of signal transducers". J. Biol. Chem. 277 (11): 9580–9. doi:10.1074/jbc.M106922200. PMID 11782456.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Gevaert K, Goethals M, Martens L, et al. (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nat. Biotechnol. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801. S2CID 23783563.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Lin KT, Lu RM, Tarn WY (2004). "The WW domain-containing proteins interact with the early spliceosome and participate in pre-mRNA splicing in vivo". Mol. Cell. Biol. 24 (20): 9176–85. doi:10.1128/MCB.24.20.9176-9185.2004. PMC 517884. PMID 15456888.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Bruneel A, Labas V, Mailloux A, et al. (2006). "Proteomics of human umbilical vein endothelial cells applied to etoposide-induced apoptosis". Proteomics. 5 (15): 3876–84. doi:10.1002/pmic.200401239. PMID 16130169. S2CID 26007149.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

TPM4

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