TMOD4
Identifiers
Aliases	TMOD4, SK-TMOD, tropomodulin 4
External IDs	OMIM: 605834; MGI: 1355285; HomoloGene: 8355; GeneCards: TMOD4; OMA:TMOD4 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q21.3 Start 151,169,986 bp[1] End 151,176,284 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3 F2.1|3 40.74 cM Start 95,031,787 bp[2] End 95,036,520 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in vastus lateralis muscle Skeletal muscle tissue of rectus abdominis tibialis anterior muscle biceps brachii muscle of thigh gastrocnemius muscle Skeletal muscle tissue of biceps brachii deltoid muscle body of tongue granulocyte Top expressed in triceps brachii muscle sternocleidomastoid muscle medial head of gastrocnemius muscle temporal muscle quadriceps femoris muscle tibialis anterior muscle vastus lateralis muscle skeletal muscle tissue muscle of thigh digastric muscle More reference expression data BioGPS n/a
Gene ontology Molecular function actin filament binding actin binding tropomyosin binding Cellular component cytoplasm cytoskeleton striated muscle thin filament myofibril Biological process pointed-end actin filament capping muscle contraction actin filament organization myofibril assembly Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 29765 50874 Ensembl ENSG00000163157 ENSMUSG00000005628 UniProt Q9NZQ9 Q9JLH8 RefSeq (mRNA) NM_013353 NM_016712 RefSeq (protein) NP_037485 NP_057921 Location (UCSC) Chr 1: 151.17 – 151.18 Mb Chr 3: 95.03 – 95.04 Mb PubMed search [3] [4]
Wikidata
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Tropomodulin 4 (muscle) also known as TMOD4 is a protein which in humans is encoded by the TMOD4 gene.^[5][6]

Function

This gene encodes a muscle-specific member of the tropomodulin family of actin-regulatory proteins. The encoded protein caps the pointed end of actin filaments preventing both elongation and depolymerization. The capping activity of this protein is dependent on its association with tropomyosin. Alternatively spliced transcript variants encoding different isoforms have been described.^[7]