PPL
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4Q28
Identifiers
Aliases	PPL, periplakin
External IDs	OMIM: 602871; MGI: 1194898; HomoloGene: 2026; GeneCards: PPL; OMA:PPL - orthologs
Gene location (Human) Chr. Chromosome 16 (human)[1] Band 16p13.3 Start 4,882,507 bp[1] End 4,960,741 bp[1]
Gene location (Mouse) Chr. Chromosome 16 (mouse)[2] Band 16 A1|16 2.5 cM Start 4,904,155 bp[2] End 4,950,285 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in oral cavity amniotic fluid mucosa of pharynx gums buccal mucosa cell gingival epithelium cervix epithelium skin of arm vulva human penis Top expressed in superior surface of tongue corneal stroma esophagus skin of external ear skin of back lip skin of abdomen epidermis belly cord hair follicle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function structural constituent of cytoskeleton protein binding cadherin binding structural molecule activity Cellular component cytoplasm cell junction plasma membrane desmosome extracellular exosome cytoskeleton membrane mitochondrion nucleus cornified envelope cytosol intermediate filament Biological process keratinization cytoskeleton organization cornification response to mechanical stimulus wound healing intermediate filament cytoskeleton organization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5493 19041 Ensembl ENSG00000118898 ENSMUSG00000039457 UniProt O60437 Q9R269 RefSeq (mRNA) NM_002705 NM_008909 RefSeq (protein) NP_002696 NP_032935 Location (UCSC) Chr 16: 4.88 – 4.96 Mb Chr 16: 4.9 – 4.95 Mb PubMed search [3] [4]
Wikidata
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Periplakin is a protein that in humans is encoded by the PPL gene.^[5][6][7]

The protein encoded by this gene is a component of desmosomes and of the epidermal cornified envelope in keratinocytes. The N-terminal domain of this protein interacts with the plasma membrane and its C-terminus interacts with intermediate filaments. Through its rod domain, this protein forms complexes with envoplakin. This protein may serve as a link between the cornified envelope and desmosomes as well as intermediate filaments. AKT1/PKB, a protein kinase mediating a variety of cell growth and survival signaling processes, is reported to interact with this protein, suggesting a possible role for this protein as a localization signal in AKT1-mediated signaling.^[7]

Interactions

PPL (gene) has been shown to interact with Keratin 8^[8] and Envoplakin.^[9][10]