16BO133病毒
16BO133病毒
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病毒分类 
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| （未分级）： | 病毒 Virus |
| 域： | 核糖病毒域 Riboviria |
| 界： | 正核糖病毒界 Orthornavirae |
| 门： | 小核糖病毒门 Pisuviricota |
| 纲： | 小南嵌套病毒纲 Pisoniviricetes |
| 目： | 套式病毒目 Nidovirales |
| 科： | 冠状病毒科 Coronaviridae |
| 属： | 乙型冠状病毒属 Betacoronavirus |
| 亚属： | SARS乙型冠状病毒亚属 Sarbecovirus |
| 种： | 严重急性呼吸道综合征相关冠状病毒 SARSr-CoV
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| 毒株： | 16BO133病毒 16BO133
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16BO133病毒是严重急性呼吸道综合征相关冠状病毒（SARSr-CoV）的一个病毒株，在韩国的马铁菊头蝠中发现，于2019年发表，其基因组被完整定序，是首个被完整定序的韩国SARSr-CoV病毒株，在SARSr-CoV中属于SARS-CoV相关病毒，与其基因组序列相似度为82.8%。
发现
[编辑]16BO133病毒于2016年在韩国马铁菊头蝠的口腔样本中被发现，此病毒株的基因组长29075nt。在SARSr-CoV中，16BO133和2016年发表、自中国吉林马铁菊头蝠中发现的JTMC15病毒最为接近，基因组核酸序列相似度为98.3%，与其他SARSr-CoV相较之下，这两个病毒株因为ORF7b末端的框移突变而丧失了ORF8[1][2]。16BO133病毒和SARS-CoV的基因组核酸序列相似度则为82.8%[3]。
过去虽有其他SARSr-CoV病毒株在韩国被发现（B15-21病毒等），但皆无完整序列定序[4]，16BO133病毒是首个被完整定序的韩国SARSr-CoV病毒株[1]。
演化树
[编辑]截至2021年1月[update]，SARS-CoV与相关病毒株的系统发生树：
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SARS-CoV-2 79 % | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
蝙蝠病毒
果子狸病毒
人类病毒
参考文献
[编辑]
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. PMID 31076983. doi:10.1007/s11262-019-01668-w （英语）.
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- ^ Na EJ, Lee SY, Kim HJ, Oem JK. Comparative genetic analyses of Korean bat coronaviruses with SARS-CoV and the newly emerged SARS-CoV-2.. J Vet Sci. 2021, 22 (1): e12. PMC 7850784 . PMID 33522164. doi:10.4142/jvs.2021.22.e12.
- ^ Kim HK, Yoon SW, Kim DJ, Koo BS, Noh JY, Kim JH; et al. Detection of Severe Acute Respiratory Syndrome-Like, Middle East Respiratory Syndrome-Like Bat Coronaviruses and Group H Rotavirus in Faeces of Korean Bats.. Transbound Emerg Dis. 2016, 63 (4): 365–72. PMC 7169817 . PMID 27213718. doi:10.1111/tbed.12515.
- ^ 5.0 5.1 Li, Wendong; Shi, Zhengli; Yu, Meng; Ren, Wuze; Smith, Craig; Epstein, Jonathan H.; Wang, Hanzhong; Crameri, Gary; Hu, Zhihong; Zhang, Huajun; Zhang, Jianhong. Bats Are Natural Reservoirs of SARS-Like Coronaviruses. Science. 2005-10-28, 310 (5748). ISSN 0036-8075. doi:10.1126/science.1118391 （英语）.
- ^ 6.0 6.1 Ge, Xing-Yi; Hu, Ben; Shi, Zheng-Li. Bat Coronaviruses. Wang, Lin-Fa (编). Bats and Viruses. Hoboken, NJ: John Wiley & Sons, Inc. 2015-06-26: 127–155. ISBN 978-1-118-81882-4. doi:10.1002/9781118818824.ch5 （英语）.
- ^ He, Biao; Zhang, Yuzhen; Xu, Lin; Yang, Weihong; Yang, Fanli; Feng, Yun; Xia, Lele; Zhou, Jihua; Zhen, Weibin; Feng, Ye; Guo, Huancheng. Perlman, S. , 编. Identification of Diverse Alphacoronaviruses and Genomic Characterization of a Novel Severe Acute Respiratory Syndrome-Like Coronavirus from Bats in China. Journal of Virology. 2014-06-15, 88 (12). ISSN 0022-538X. PMC 4054348 . PMID 24719429. doi:10.1128/JVI.00631-14 （英语）.
- ^ 8.0 8.1 Lau, Susanna K. P.; Feng, Yun; Chen, Honglin; Luk, Hayes K. H.; Yang, Wei-Hong; Li, Kenneth S. M.; Zhang, Yu-Zhen; Huang, Yi; Song, Zhi-Zhong; Chow, Wang-Ngai; Fan, Rachel Y. Y. Perlman, S. , 编. Severe Acute Respiratory Syndrome (SARS) Coronavirus ORF8 Protein Is Acquired from SARS-Related Coronavirus from Greater Horseshoe Bats through Recombination. Journal of Virology. 2015-10-15, 89 (20). ISSN 0022-538X. PMC 4580176 . PMID 26269185. doi:10.1128/JVI.01048-15 （英语）.
- ^ 9.0 9.1 Ge, Xing-Yi; Li, Jia-Lu; Yang, Xing-Lou; Chmura, Aleksei A.; Zhu, Guangjian; Epstein, Jonathan H.; Mazet, Jonna K.; Hu, Ben; Zhang, Wei; Peng, Cheng; Zhang, Yu-Ji. Isolation and characterization of a bat SARS-like coronavirus that uses the ACE2 receptor. Nature. 2013-11, 503 (7477). Bibcode:2013Natur.503..535G. ISSN 0028-0836. PMC 5389864 . PMID 24172901. doi:10.1038/nature12711 （英语）.
- ^ Yang, Xing-Lou; Hu, Ben; Wang, Bo; Wang, Mei-Niang; Zhang, Qian; Zhang, Wei; Wu, Li-Jun; Ge, Xing-Yi; Zhang, Yun-Zhi; Daszak, Peter; Wang, Lin-Fa. Perlman, S. , 编. Isolation and Characterization of a Novel Bat Coronavirus Closely Related to the Direct Progenitor of Severe Acute Respiratory Syndrome Coronavirus. Journal of Virology. 2016-03-15, 90 (6). ISSN 0022-538X. PMC 4810638 . PMID 26719272. doi:10.1128/JVI.02582-15 （英语）.
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