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严重急性呼吸综合征冠状病毒2-Lambda变异株

严重急性呼吸综合征冠状病毒2-Lambda变异株(英语:SARS-CoV-2 Lambda variant),别名C.37谱系(英语:Lineage C.37),是严重急性呼吸综合征冠状病毒2(导致2019冠状病毒疾病病毒)的变异株[1]它于2020年12月在秘鲁首次被发现。[1] 2021年6月14日,世界卫生组织希腊字母Λ将其命名为Lambda变异株[1]并宣布其为“需留意变异株”(VOI)。 [2]截至2021年8月初,它已传播到全球至少30个国家[3] ,并且与其他株相比,它对2019冠状病毒疾病疫苗的免疫力更强。[4] [5]还有人认为,Lambda变异株比B.1.1.7谱系(Alpha变异株)或Gamma变异株更具传染性[4]

原本仅在中南美洲扩散的Lambda变种病毒,于2021年 8 月 15 日 在菲律宾出现Lambda变种病毒本土案例,显示该变种病毒已进入亚洲。[6]

变异

Lambda变异株基因的氨基酸突变点位皆位于其棘蛋白编码上,分别为:G75V、T76I、Δ246-252、L452Q、F490S、D614G及T859N[7]

参见

参考文献

  1. ^ 1.0 1.1 1.2 Tracking SARS-CoV-2 variants. World Health Organization. [2021-06-17]. (原始内容存档于2021-06-09) (英语). 
  2. ^ Tracking SARS-CoV-2 variants. who.int. World Health Organization. [2021-08-08]. (原始内容存档于2021-06-18) (英语).  Updated frequently.
  3. ^ Covid 19 coronavirus: Ultra-contagious Lambda variant detected in Australia. New Zealand Herald. 2021-07-06 [2021-08-08]. (原始内容存档于2021-07-12). 
  4. ^ 4.0 4.1 COVID-19: Lambda variant may be more resistant to vaccines than other strains. World Is One News. 2021-07-06 [2021-08-08]. (原始内容存档于2021-07-11). 
  5. ^ Lambda variant: What is the new strain of Covid detected in the UK?. The Independent. 2021-07-06 [2021-08-08]. (原始内容存档于2021-07-22). 
  6. ^ Delta 变种病毒来势汹汹!台湾准备好了吗?页面存档备份,存于互联网档案馆),基因线上
  7. ^ Robertson, Sally. Lambda lineage of SARS-CoV-2 has potential to become variant of concern. news-medical.net. 27 June 2021 [2021-07-05]. (原始内容存档于2021-08-25). The Lambda variant also contained a novel deletion (Δ246-252) and multiple nonsynonymous mutations (G75V, T76I, L452Q, F490S, D614G, and T859N) in the gene that encodes the viral spike protein. 
  8. ^ Spike Variants: Lambda variant, aka B.1.1.1. covdb.stanford.edu. Stanford University Coronavirus Antiviral & Resistance Database. 1 July 2021 [2021-07-05]. (原始内容存档于2021-06-30). 
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严重急性呼吸综合征冠状病毒2-Lambda变异株
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