Lobelin
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| IUPAC ime | |
|---|---|
2-((2R,6S)-6-((S)-2-Hidroksi-2-feniletil)-1-metilpiperidin-2-il)-1-feniletanon | |
| Klinički podaci | |
| Drugs.com | Internacionalno ime leka |
| Identifikatori | |
| CAS broj | 90-69-7  |
| ATCvet kod | QV04CV01 (WHO) |
| PubChem | CID 101616 |
| ChemSpider | 91814  |
| UNII | D0P25S3P81 |
| KEGG | D02364 |
| ChEMBL | CHEMBL15476 |
| Hemijski podaci | |
| Formula | C22H27NO2 |
| Molarna masa | 337,455 |
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Lobelin je prirodni alkaloid prisutan u biljkama Lobelia inflata, Lobelia tupa, Lobelia cardinalis, Lobelia siphilitica, i Hippobroma longiflora. U svojoj čistoj formi on je beli amorfni prah koji je rastvoran u vodi.
Lobelin kao pomoćno sredstvo za potiskivanje želje za pušenjem,[1][2][3] a moguće je da primenljiv i kod drugih tipova zavisnosti, kao što je adikcija na amfetamin,[4][5] kokain[6] ili alkohol.[7]
Reference
[уреди | уреди извор]- ^ Stead LF, Hughes JR (2012). „Lobeline for smoking cessation”. Cochrane Database Syst Rev. 2012 (2): CD000124. PMC 7043274
. PMID 22336780. doi:10.1002/14651858.CD000124.pub2.
- ^ Marlow, S. P.; Stoller, J. K. (2003). „Smoking cessation”. Respiratory Care. 48 (12): 1238—54; discussion 1254—6. PMID 14651764.
- ^ Buchhalter, A. R.; Fant, R. V.; Henningfield, J. E. (2008). „Novel pharmacological approaches for treating tobacco dependence and withdrawal: Current status”. Drugs. 68 (8): 1067—1088. PMID 18484799. S2CID 46875770. doi:10.2165/00003495-200868080-00005.
- ^ Neugebauer, Nichole M.; Harrod, Steven B.; Stairs, Dustin J.; Crooks, Peter A.; Dwoskin, Linda P.; Bardo, Michael T. (2007). „Lobelane decreases methamphetamine self-administration in rats”. European Journal of Pharmacology. 571 (1): 33—38. PMC 2104779 . PMID 17612524. doi:10.1016/j.ejphar.2007.06.003.
- ^ Eyerman, D. J.; Yamamoto, B. K. (2005). „Lobeline attenuates methamphetamine-induced changes in vesicular monoamine transporter 2 immunoreactivity and monoamine depletions in the striatum”. The Journal of Pharmacology and Experimental Therapeutics. 312 (1): 160—169. PMID 15331654. S2CID 19787823. doi:10.1124/jpet.104.072264.
- ^ Polston, J. E.; Cunningham, C. S.; Rodvelt, K. R.; Miller, D. K. (2006). „Lobeline augments and inhibits cocaine-induced hyperactivity in rats”. Life Sciences. 79 (10): 981—990. PMID 16765386. doi:10.1016/j.lfs.2006.05.006.
- ^ Farook, J. M.; Lewis, B.; Gaddis, J. G.; Littleton, J. M.; Barron, S. (2009). „Lobeline, a nicotinic partial agonist attenuates alcohol consumption and preference in male C57BL/6J mice”. Physiology & Behavior. 97 (3–4): 503—506. PMID 19268674. S2CID 23762679. doi:10.1016/j.physbeh.2009.02.031.
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