4-Me-αMT
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| IUPAC ime | |
|---|---|
1-metil-2-(4-metil-1H-indol-3-il)-etilamin | |
| Klinički podaci | |
| Način primene | Oralno |
| Pravni status | |
| Pravni status |
|
| Identifikatori | |
| CAS broj | 3569-29-7  |
| ATC kod | none |
| PubChem | CID 28806639 |
| ChemSpider | 25392939 |
| UNII | QY99ES7YWD |
| Hemijski podaci | |
| Formula | C12H16N2 |
| Molarna masa | 188,27 g·mol−1 |
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4-Metil-α-metiltriptamin (4-Me-αMT), takođe poznat kao 4,α-dimetiltriptamin (4,α-DMT), i MP-809, je lek koji pripada triptaminskoj klasi. On je istraživan kao antidepresant tokom ranih 1960-ih ali nije plasiran na tržište.[1][2] 4-Me-αMT je organsko jedinjenje, koje sadrži 12 atoma ugljenika i ima molekulsku masu od 188,269 Da.
Osobine
[уреди | уреди извор]| Osobina | Vrednost |
|---|---|
| Broj akceptora vodonika | 1 |
| Broj donora vodonika | 2 |
| Broj rotacionih veza | 2 |
| Particioni koeficijent[3] (ALogP) | 2,4 |
| Rastvorljivost[4] (logS, log(mol/L)) | -3,5 |
| Polarna površina[5] (PSA, Å2) | 41,8 |
Vidi još
[уреди | уреди извор]- 4-Metil-αET
- α-Etiltriptamin (αET)
- α-Metiltriptamin (αMT)
Reference
[уреди | уреди извор]- ^ Azima H, Arthurs D, Silver A, Azima FJ (децембар 1962). „The effect of MP-809 in depressive states: a multi-blind study”. The American Journal of Psychiatry. 119 (6): 573—4. PMID 13965759. doi:10.1176/ajp.119.6.573.
- ^ Brodey JF, Steiner WG, Himwich HE (април 1963). „An electrographic study of psilocin and 4-methyl-alpha-methyl tryptamine (MP-809)”. The Journal of Pharmacology and Experimental Therapeutics. 140: 8—18. PMID 14015664.
- ^ Ghose, A.K.; Viswanadhan V.N. & Wendoloski, J.J. (1998). „Prediction of Hydrophobic (Lipophilic) Properties of Small Organic Molecules Using Fragment Methods: An Analysis of AlogP and CLogP Methods”. J. Phys. Chem. A. 102: 3762—3772. doi:10.1021/jp980230o.
- ^ Tetko IV, Tanchuk VY, Kasheva TN, Villa AE (2001). „Estimation of Aqueous Solubility of Chemical Compounds Using E-State Indices”. Chem Inf. Comput. Sci. 41: 1488—1493. PMID 11749573. doi:10.1021/ci000392t.
- ^ Ertl P.; Rohde B.; Selzer P. (2000). „Fast calculation of molecular polar surface area as a sum of fragment based contributions and its application to the prediction of drug transport properties”. J. Med. Chem. 43: 3714—3717. PMID 11020286. doi:10.1021/jm000942e.
Literatura
[уреди | уреди извор]- Hardman JG, Limbird LE, Gilman AG (2001). Goodman & Gilman's The Pharmacological Basis of Therapeutics (10. изд.). New York: McGraw-Hill. ISBN 0071354697. doi:10.1036/0071422803.
- Thomas L. Lemke; David A. Williams, ур. (2007). Foye's Principles of Medicinal Chemistry (6. изд.). Baltimore: Lippincott Willams & Wilkins. ISBN 0781768799.
Spoljašnje veze
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