Rev-Erb
![](https://upload.wikimedia.org/wikipedia/commons/thumb/0/03/Model_of_REV-ERB-mediated_Circadian_Gene_Expression.png/400px-Model_of_REV-ERB-mediated_Circadian_Gene_Expression.png)
nuclear receptor subfamily 1, group D, member 1 | |||||||
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Identifiers | |||||||
Symbol | NR1D1 | ||||||
Alt. symbols | ear-1, hRev, Rev-ErbAalpha, THRA1 | ||||||
NCBI gene | 9572 | ||||||
HGNC | 7962 | ||||||
OMIM | 602408 | ||||||
RefSeq | NM_021724 | ||||||
UniProt | P20393 | ||||||
Other data | |||||||
Locus | Chr. 17 q11.2 | ||||||
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nuclear receptor subfamily 1, group D, member 2 | |||||||
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Identifiers | |||||||
Symbol | NR1D2 | ||||||
Alt. symbols | BD73, RVR, EAR-1r, HZF2, Hs.37288 | ||||||
NCBI gene | 9975 | ||||||
HGNC | 7963 | ||||||
OMIM | 602304 | ||||||
RefSeq | XM_001130839 | ||||||
UniProt | Q14995 | ||||||
Other data | |||||||
Locus | Chr. 3 p24.1 | ||||||
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The Rev-Erb proteins are members of the nuclear receptor (NR) superfamily of intracellular transcription factors and key regulatory components of the circadian clock. There are two forms of the receptor, Rev-Erb alpha and Rev-Erb beta, which are each encoded by a separate gene (NR1D1 and NR1D2, respectively).[1][2]
These proteins act as key regulators of clock gene expression through transcriptional repression of Bmal1. Through their regulation of clock-controlled genes, the Rev-Erb proteins affect several physiological processes throughout the body, including metabolic, endocrine, and immune pathways.[3][4][5]
In the NRNC classification scheme, Rev-Erb is nuclear receptor subfamily 1 group D (NR1D). The name "Rev-Erb" derived by truncation from "Rev-ERBA" (Rev-Erbα), which in turn was named because it was on the opposite strand of ERBA (THRA) oncogene. The paralogous Rev-Erbβ does not seem to have anything special on its reverse strand. Older sources may use "Rev-ERBA" as the family name.[6]
The receptors are potential drug targets for non-alcoholic steatohepatitis.[7]
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