IRX2
IRX2 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Aliases | IRX2, IRXA2, iroquois homeobox 2 | ||||||||||||||||||||||||||||||||||||||||||||||||||
External IDs | OMIM: 606198; MGI: 1197526; HomoloGene: 56490; GeneCards: IRX2; OMA:IRX2 - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Wikidata | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Iroquois-class homeodomain protein IRX-2, also known as Iroquois homeobox protein 2, is a protein that in humans is encoded by the IRX2 gene.[5][6]
Function
IRX2 is a member of the Iroquois homeobox gene family. Members of this family appear to play multiple roles during pattern formation of vertebrate embryos.[5]
Cancer
IRX2 gene has been observed progressively downregulated in Human papillomavirus-positive neoplastic keratinocytes derived from uterine cervical preneoplastic lesions at different levels of malignancy. [7] For this reason, IRX2 is likely to be associated with tumorigenesis and may be a potential prognostic marker for uterine cervical preneoplastic lesions progression. [7]
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