KLF6
Identifiers
Aliases	KLF6, BCD1, CBA1, COPEB, CPBP, GBF, PAC1, ST12, ZF9, Kruppel-like factor 6, Kruppel like factor 6
External IDs	OMIM: 602053; MGI: 1346318; HomoloGene: 996; GeneCards: KLF6; OMA:KLF6 - orthologs
Gene location (Human) Chr. Chromosome 10 (human)[1] Band 10p15.2 Start 3,775,996 bp[1] End 3,785,281 bp[1]
Gene location (Mouse) Chr. Chromosome 13 (mouse)[2] Band 13|13 A1 Start 5,911,481 bp[2] End 5,920,393 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in nipple lower lobe of lung skin of thigh saphenous vein vena cava pericardium gastric mucosa skin of hip monocyte synovial joint Top expressed in granulocyte stroma of bone marrow aortic valve ascending aorta sciatic nerve endothelial cell of lymphatic vessel left colon tunica media of zone of aorta right lung lobe blood More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding protein binding metal ion binding nucleic acid binding RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific double-stranded DNA binding Cellular component fibrillar center nucleus nucleolus cytosol intracellular membrane-bounded organelle Biological process positive regulation of transcription, DNA-templated B cell differentiation regulation of transcription, DNA-templated transcription, DNA-templated positive regulation of transcription by RNA polymerase II transcription by RNA polymerase II regulation of transcription by RNA polymerase II cytokine-mediated signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1316 23849 Ensembl ENSG00000067082 ENSMUSG00000000078 UniProt Q99612 O08584 Q8BPQ2 RefSeq (mRNA) NM_001008490 NM_001160124 NM_001160125 NM_001300 NM_011803 RefSeq (protein) NP_001153596 NP_001153597 NP_001291 NP_035933 Location (UCSC) Chr 10: 3.78 – 3.79 Mb Chr 13: 5.91 – 5.92 Mb PubMed search [3] [4]
Wikidata
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Krueppel-like factor 6 is a protein that in humans is encoded by the KLF6 gene.^[5]

It is a tumor suppressor gene.^[6]

Function

This gene encodes a nuclear protein that has three zinc fingers at the end of its C-terminal domain, a serine/threonine-rich central region, and an acidic domain lying within the N-terminal region. The zinc fingers of this protein are responsible for the specific DNA binding with the guanine-rich core promoter elements. The central region might be involved in activation or posttranslational regulatory pathways, and the acidic N-terminal domain might play an important role in the process of transcriptional activation. It is capable of activating transcription approximately 4-fold either on homologous or heterologous promoters. The DNA binding and transcriptional activity of this protein, in conjunction with its expression pattern, suggests that this protein may participate in the regulation and/or maintenance of the basal expression of pregnancy-specific glycoprotein genes and possibly other TATA box-less genes. Two transcript variants encoding the same protein have been found for this gene.^[7]

Interactions

KLF6 has been shown to interact with Sp1 transcription factor.^[8]