BICD2
Identifiers
Aliases	BICD2, SMALED2, bA526D8.1, BICD cargo adaptor 2, SMALED2B, SMALED2A
External IDs	OMIM: 609797; MGI: 1924145; HomoloGene: 9070; GeneCards: BICD2; OMA:BICD2 - orthologs
Gene location (Human) Chr. Chromosome 9 (human)[1] Band 9q22.31 Start 92,711,363 bp[1] End 92,764,833 bp[1]
Gene location (Mouse) Chr. Chromosome 13 (mouse)[2] Band 13|13 A5 Start 49,495,061 bp[2] End 49,540,502 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gingival epithelium hair follicle human penis nipple vulva skin of arm oral cavity skin of thigh skin of hip mucosa of pharynx Top expressed in Rostral migratory stream internal carotid artery external carotid artery trigeminal ganglion interventricular septum myocardium of ventricle right lung lobe skin of external ear retinal pigment epithelium atrioventricular valve More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding dynein light intermediate chain binding dynactin binding dynein complex binding cytoskeletal anchor activity Cellular component plasma membrane Golgi apparatus cytoskeleton cytoplasmic vesicle nucleus nuclear envelope lamellae anulatae nuclear pore cytoplasm cytosol centrosome Biological process microtubule-based movement minus-end-directed organelle transport along microtubule microtubule anchoring at microtubule organizing center retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum protein transport mRNA transport centrosome localization transport protein localization to Golgi apparatus regulation of microtubule cytoskeleton organization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 23299 76895 Ensembl ENSG00000185963 ENSMUSG00000037933 UniProt Q8TD16 Q921C5 RefSeq (mRNA) NM_015250 NM_001003800 NM_001039179 NM_001039180 NM_029791 RefSeq (protein) NP_001003800 NP_056065 NP_001034268 NP_001034269 NP_084067 Location (UCSC) Chr 9: 92.71 – 92.76 Mb Chr 13: 49.5 – 49.54 Mb PubMed search [3] [4]
Wikidata
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Bicaudal D cargo adaptor 2 is a protein that in humans is encoded by the BICD2 gene.^[5][6]

This gene is one of two human homologs of Drosophila bicaudal-D and a member of the Bicoid family. It has been implicated in dynein-mediated, minus end-directed motility along microtubules. It has also been reported to be a phosphorylation target of NIMA related kinase 8. Two alternative splice variants have been described.^[6]

Mutations in BICD2 are associated with spinal muscular atrophy with lower extremity predominance type 2A and type 2B.