NFYB
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1N1J, 4AWL, 4CSR
Identifiers
Aliases	NFYB, CBF-A, CBF-B, HAP3, NF-YB, nuclear transcription factor Y subunit beta
External IDs	OMIM: 189904; MGI: 97317; HomoloGene: 38149; GeneCards: NFYB; OMA:NFYB - orthologs
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12q23.3 Start 104,117,086 bp[1] End 104,138,241 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10 C1|10 40.25 cM Start 82,584,535 bp[2] End 82,599,978 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ganglionic eminence Achilles tendon ventricular zone endothelial cell right coronary artery seminal vesicula left coronary artery tibial arteries Descending thoracic aorta muscle layer of sigmoid colon Top expressed in primitive streak epiblast ganglionic eminence saccule otic vesicle embryo ventricular zone maxillary prominence Rostral migratory stream Region I of hippocampus proper More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA-binding transcription factor activity sequence-specific DNA binding protein binding protein heterodimerization activity DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific protein-containing complex binding Cellular component protein-DNA complex nucleoplasm CCAAT-binding factor complex nucleus RNA polymerase II transcription regulator complex Biological process positive regulation of transcription, DNA-templated transcription, DNA-templated regulation of transcription, DNA-templated regulation of cholesterol biosynthetic process cellular response to leukemia inhibitory factor regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4801 18045 Ensembl ENSG00000120837 ENSMUSG00000020248 UniProt P25208 P63139 RefSeq (mRNA) NM_006166 NM_010914 RefSeq (protein) NP_006157 NP_006157.1 NP_035044 Location (UCSC) Chr 12: 104.12 – 104.14 Mb Chr 10: 82.58 – 82.6 Mb PubMed search [3] [4]
Wikidata
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Nuclear transcription factor Y subunit beta is a protein that in humans is encoded by the NFYB gene.^[5][6]

Function

The protein encoded by this gene is one subunit of a trimeric complex, forming a highly conserved transcription factor that binds with high specificity to CCAAT motifs in the promoter regions in a variety of genes. This gene product, subunit B, forms a tight dimer with the C subunit, a prerequisite for subunit A association. The resulting trimer binds to DNA with high specificity and affinity. Subunits B and C each contain a histone-like motif. Observation of the histone nature of these subunits is supported by two types of evidence; protein sequence alignments and experiments with mutants.^[7]

Interactions

NFYB has been shown to interact with:

• CEBPZ,^[8]
• CNTN2,^[9]
• Myc,^[10] and
• TBP^[11]