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头孢泊肟酯

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头孢泊肟酯
临床资料
商品名英语Drug nomenclatureGeneric (formerly Vantin)
AHFS/Drugs.comMonograph
MedlinePlusa698024
怀孕分级
给药途径Oral
ATC码
法律规范状态
法律规范
药物动力学数据
生物利用度50%
血浆蛋白结合率21% to 29%
药物代谢基本没有代谢, 头孢泊肟酯经肝脏代谢成头孢泊肟
生物半衰期小时
排泄途径Renal, 不吸收的药物经胃肠道由粪便排泄;约80%的头孢泊肟酯以原型从尿液中排泄,极小部分经胆道排泄
识别信息
  • (6R,7R)-7[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-methoxyimino-acetyl]amino3-(methoxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
    (6R,7R)-7-[2-(2-氨基-4-噻唑基)-(Z)-2-(甲氧亚氨基)-乙酰氨基]-3-甲氧甲基-8-氧代-5-硫杂-1-氮杂双环-[4.2.0]辛-2-烯-2-甲酸异丙氧羰基氧乙酯
CAS号82619-04-3  checkY
PubChem CID
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
CompTox Dashboard英语CompTox Chemicals Dashboard (EPA)
ECHA InfoCard100.210.871 编辑维基数据链接
化学信息
化学式C15H17N5O6S2
摩尔质量427.45 g·mol−1
3D模型(JSmol英语JSmol
  • O=C2N1/C(=C(\CS[C@@H]1[C@@H]2NC(=O)C(=N\OC)/c3nc(sc3)N)COC)C(=O)O
  • InChI=1S/C15H17N5O6S2/c1-25-3-6-4-27-13-9(12(22)20(13)10(6)14(23)24)18-11(21)8(19-26-2)7-5-28-15(16)17-7/h5,9,13H,3-4H2,1-2H3,(H2,16,17)(H,18,21)(H,23,24)/b19-8-/t9-,13-/m1/s1 checkY
  • Key:WYUSVOMTXWRGEK-HBWVYFAYSA-N checkY

头孢泊肟酯(英语:Cefpodoxime Proxetil),是一种第三代头孢菌素。 它对绝大多数的革兰氏阳性革兰氏阴性的生物都有作用,除了绿脓杆菌肠球菌脆弱拟杆菌英语Bacteroides fragilis等例外。现在它在美国仍然在常规准备阶段,通常用于治疗急性中耳炎咽炎鼻窦炎和淋病。


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头孢泊肟酯
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