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培那西林

培那西林
临床资料
AHFS/Drugs.com国际药品名称
ATC码
识别信息
  • (acetyloxy)methyl (2S,5R,6R)-3,3-dimethyl-7-oxo-6-[(phenylacetyl)amino]-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate
CAS号983-85-7  checkY
PubChem CID
ChemSpider
UNII
KEGG
ChEBI
CompTox Dashboard英语CompTox Chemicals Dashboard (EPA)
ECHA InfoCard100.012.338 编辑维基数据链接
化学信息
化学式C19H22N2O6S
摩尔质量406.45 g·mol−1
3D模型(JSmol英语JSmol
  • CC(=O)OCOC(=O)[C@H]1C(S[C@H]2N1C(=O)[C@H]2NC(=O)CC3=CC=CC=C3)(C)C
  • InChI=1S/C19H22N2O6S/c1-11(22)26-10-27-18(25)15-19(2,3)28-17-14(16(24)21(15)17)20-13(23)9-12-7-5-4-6-8-12/h4-8,14-15,17H,9-10H2,1-3H3,(H,20,23)/t14-,15+,17-/m1/s1 ☒N
  • Key:NLOOMWLTUVBWAW-HLLBOEOZSA-N ☒N

培那西林(英语:Penamecillin)是苄青霉素的乙酰氧基甲酯,是一种通过酯酶加工成苄青霉素的前体药物[1]

一项研究表明,怀孕期间口服培那西林治疗未对胎儿造成可检测的致畸风险。[2]

参考资料

[编辑]
  1. ^ Agersborg HP, Batchelor A, Cambridge GW, Rule AW. The pharmacology of penamecillin. British Journal of Pharmacology and Chemotherapy. March 1966, 26 (3): 649–55. PMC 1510697可免费查阅. PMID 4959939. doi:10.1111/j.1476-5381.1966.tb01844.x. 
  2. ^ Andrew Czeizel. 青霉素V的安全性:妊娠期间口服培那西林的使用召回偏差的重要性和局限性 The Safety of Penicillin V: Oral Penamecillin Use During Pregnancy The Importance and Limitation of Recall Bias. [2023-03-01]. (原始内容存档于2023-03-01) (英语). 
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培那西林
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