SQ109
| SQ109 | |
|---|---|
| |
| IUPAC名 N1-(Adamantan-2-yl)-N2-[(2E)-3,7-dimethylocta-2,6-dien-1-yl]ethane-1,2-diamine | |
| 识别 | |
| CAS号 | 502487-67-4 
|
| PubChem | 5274428 |
| SMILES |
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| IUPHAR配体 | 7997 |
| 性质 | |
| 化学式 | C22H38N2 |
| 摩尔质量 | 330.55 g·mol−1 |
| 若非注明，所有数据均出自标准状态（25 ℃，100 kPa）下。 | |
SQ109是一种开发中的抗分枝杆菌药物，靶点为分枝杆菌的MMPL3蛋白（mycobacterial membrane protein large 3，分枝杆菌膜蛋白3）。[1][2]
参考文献
[编辑]- ^ Jia, L; Tomaszewski, JE; Hanrahan, C; Coward, L; Noker, P; Gorman, G; Nikonenko, B; Protopopova, M. Pharmacodynamics and pharmacokinetics of SQ109, a new diamine-based antitubercular drug.. British journal of pharmacology. 2005-01, 144 (1): 80–7. PMID 15644871. doi:10.1038/sj.bjp.0705984.
- ^ Meng, Q; Luo, H; Liu, Y; Li, W; Zhang, W; Yao, Q. Synthesis and evaluation of carbamate prodrugs of SQ109 as antituberculosis agents.. Bioorganic & medicinal chemistry letters. 2009-05-15, 19 (10): 2808–10. PMID 19362471. doi:10.1016/j.bmcl.2009.03.091.
外部链接
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