丁烯沙林
| 丁烯沙林 | |
|---|---|
| |
| IUPAC名 (2E)-But-2-en-1-yl methylphosphonofluoridate | |
| 别名 | CRS 2-丁烯基-P-甲基膦酰氟 |
| 识别 | |
| CAS号 | 138780-00-4（2E） 
|
| PubChem | 6438716 |
| ChemSpider | 4943171 |
| SMILES |
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| 性质 | |
| 化学式 | C5H10FO2P |
| 摩尔质量 | 152.1 g·mol−1 |
| 若非注明，所有数据均出自标准状态（25 ℃，100 kPa）下。 | |
丁烯沙林（CRS）是G系列内一种剧毒的有机磷神经性毒剂。[1]CRS像其他神经性毒剂一样，会不可逆转地抑制乙酰胆碱酯酶。然而，因为所抑制的酶很快老化，所以它不能被肟活化剂活化。[2][3]
参见
[编辑]参考文献
[编辑]- ^ Worek, Franz; Wille, Timo; Koller, Marianne; Thiermann, Horst. Toxicology of organophosphorus compounds in view of an increasing terrorist threat. Archives of Toxicology. 27 June 2016, 90 (9): 2131–2145. PMID 27349770. S2CID 15724842. doi:10.1007/s00204-016-1772-1.
- ^ Busker, R.W.; Zijlstra, J.J.; van der Wiel, H.J.; Melchers, B.P.C.; van Helden, H.P.M. Organophosphate poisoning: a method to test therapeutic effects of oxamines other than acetylcholinesterase activation in the rat. Toxicology. January 1991, 69 (3): 331–344. PMID 1658986. doi:10.1016/0300-483x(91)90191-3.
- ^ Soukup, O.; Jun, D.; Tobin, G.; Kuca, K. The summary on non-reactivation cholinergic properties of oxime reactivators: the interaction with muscarinic and nicotinic receptors. Archives of Toxicology. 21 November 2012, 87 (4): 711–719. PMID 23179755. S2CID 18252681. doi:10.1007/s00204-012-0977-1.
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