LHX2
LIM同源框蛋白質 LHX2是蛋白質的一種，在人類內由「LHX2」基因所編碼。[5][6][7]
LHX2包含LIM結構域，这是一種帶有許多半胱氨酸，具鋅指結構的結構域。該蛋白質的作用為轉錄調控。該蛋白質在果蠅體內，可用來回復由其他蛋白質引起的表型，推測是在演化時留下的功能[7]。
交互作用
[编辑]參考資料
[编辑]- ^ 1.0 1.1 1.2 GRCh38: Ensembl release 89: ENSG00000106689 - Ensembl, May 2017
- ^ 2.0 2.1 2.2 GRCm38: Ensembl release 89: ENSMUSG00000000247 - Ensembl, May 2017
- ^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Wu HK, Heng HH, Siderovski DP, Dong WF, Okuno Y, Shi XM, Tsui LC, Minden MD. Identification of a human LIM-Hox gene, hLH-2, aberrantly expressed in chronic myelogenous leukaemia and located on 9q33-34.1. Oncogene. Jul 1996, 12 (6): 1205–12. PMID 8649822.
- ^ Rincon-Limas DE, Lu CH, Canal I, Calleja M, Rodriguez-Esteban C, Izpisua-Belmonte JC, Botas J. Conservation of the expression and function of apterous orthologs in Drosophila and mammals. Proc Natl Acad Sci U S A. Apr 1999, 96 (5): 2165–70. PMC 26754
. PMID 10051612. doi:10.1073/pnas.96.5.2165.
- ^ 7.0 7.1 Entrez Gene: LHX2 LIM homeobox 2.
- ^ Glenn, D J; Maurer R A. MRG1 binds to the LIM domain of Lhx2 and may function as a coactivator to stimulate glycoprotein hormone alpha-subunit gene expression. J. Biol. Chem. (UNITED STATES). Dec 1999, 274 (51): 36159–67. ISSN 0021-9258. PMID 10593900. doi:10.1074/jbc.274.51.36159.
延伸閱讀
[编辑]- Gerhard DS, Wagner L, Feingold EA et al. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004, 14 (10B): 2121–7. PMC 528928 . PMID 15489334. doi:10.1101/gr.2596504.
- Ota T, Suzuki Y, Nishikawa T et al. Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat. Genet. 2004, 36 (1): 40–5. PMID 14702039. doi:10.1038/ng1285.
- Strausberg RL, Feingold EA, Grouse LH et al. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc. Natl. Acad. Sci. U.S.A. 2003, 99 (26): 16899–903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899.
- Glenn DJ, Maurer RA. MRG1 binds to the LIM domain of Lhx2 and may function as a coactivator to stimulate glycoprotein hormone alpha-subunit gene expression. J. Biol. Chem. 2000, 274 (51): 36159–67. PMID 10593900. doi:10.1074/jbc.274.51.36159.
- Bach I, Rodriguez-Esteban C, Carrière C et al. RLIM inhibits functional activity of LIM homeodomain transcription factors via recruitment of the histone deacetylase complex. Nat. Genet. 1999, 22 (4): 394–9. PMID 10431247. doi:10.1038/11970.
- Bendall AJ, Rincón-Limas DE, Botas J, Abate-Shen C. Protein complex formation between Msx1 and Lhx2 homeoproteins is incompatible with DNA binding activity. Differentiation. 1998, 63 (3): 151–7. PMID 9697309. doi:10.1046/j.1432-0436.1998.6330151.x.
| |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Text is available under the CC BY-SA 4.0 license; additional terms may apply.
Images, videos and audio are available under their respective licenses.
Cover photo is available under {{::mainImage.info.license.name || 'Unknown'}} license.
Cover photo is available under {{::mainImage.info.license.name || 'Unknown'}} license.
Credit:
(see original file).
