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氟他唑仑 .
氟他唑仑 臨床資料 商品名 Coreminal (JP ) 其他名稱 10-氯-11b -(2-氟苯基)-7-(2-羟乙基)-3,5-二氢-2H -[1,3]噁唑并[3,2-d ][1,4]苯二氮䓬-6-酮 13-氯-2-(2-氟苯基)-9-(2-羟乙基)-3-氧杂-6,9-二氮杂三环[8.4.0.02,6 ]十四碳-1(10),11,13-三烯-8-酮 氟噁唑兰 氟太唑仑 氟噁二氮唑 MS-4101 AHFS /Drugs.com 国际药品名称 给药途径 Oral 法律規範狀態 法律規範
美 : 未列入管制
In general: unscheduled, Rx-only in Japan
藥物動力學 數據药物代谢 Hepatic 生物半衰期 3.5 小时 (parent compound); 47-100 小时 (major metabolite) 识别信息
10-chloro-11b -(2-fluorophenyl)-7-(2-hydroxyethyl)-3,5-dihydro-2H -[1,3]oxazolo[3,2-d ][1,4]benzodiazepin-6-one
CAS号 27060-91-9 Y PubChem CID ChemSpider UNII KEGG ChEMBL CompTox Dashboard (EPA ) 化学信息 化学式 C 19 H 18 Cl F N 2 O 3 摩尔质量 376.81 g·mol−1 3D模型(JSmol )
Fc1ccccc1C42OCCN2CC(=O)N(c3c4cc(Cl)cc3)CCO
InChI=1S/C19H18ClFN2O3/c20-13-5-6-17-15(11-13)19(14-3-1-2-4-16(14)21)22(8-10-26-19)12-18(25)23(17)7-9-24/h1-6,11,24H,7-10,12H2
Y Key:WMFSSTNVXWNLKI-UHFFFAOYSA-N
Y
氟他唑仑 (分子式:C19 H18 ClFN2 O3 )是一种苯二氮䓬类 药物。[1] 它在日本发明,这也是在医学上有使用的主要国家。它具有镇静 、肌肉松弛 、抗惊厥 和抗焦虑 作用,与其它苯二氮䓬类药物的作用相似。虽然它和地西泮 的效力大致相同,但它有更显著的镇静作用和协调障碍。它适用于失眠 的治疗。[2] 它的主要活性代谢产物是去烷基氟西泮 ,这同时也是氟西泮 的主要代谢产物。[3] 氟他唑仑的半衰期非常短,仅3.5小时,而去烷基氟西泮的半衰期常大47–100小时。[4]
^ DE 1952486
^ Mitsushima T, Ueki S. Psychopharmacological effects of flutazolam (MS-4101)(日語) . Nippon Yakurigaku Zasshi . 1978 Nov;74(8):959-79.
^ Miyaguchi H, Kuwayama K, Tsujikawa K, Kanamori T, Iwata YT, Inoue H, Kishi T. A method for screening for various sedative-hypnotics in serum by liquid chromatography/single quadrupole mass spectrometry. Forensic Science International. February 2006, 157 (1): 57–70. PMID 15869852 . doi:10.1016/j.forsciint.2005.03.011 .
^ Dalmane Prescribing Information (PDF) . Prescribing Information for Dalmane. FDA. [3 April 2022] . (原始内容存档 (PDF) 于2022-11-24).
醇 巴比妥类 苯二氮䓬类 氨基甲酸酯类 黄酮类 咪唑类 卡瓦醉辣成分
10-Methoxyyangonin
11-Methoxyyangonin
11-Hydroxyyangonin
Desmethoxyyangonin
11-Methoxy-12-hydroxydehydrokavain
7,8-Dihydroyangonin
Kavain
5-Hydroxykavain
5,6-Dihydroyangonin
7,8-Dihydrokavain
5,6,7,8-Tetrahydroyangonin
5,6-Dehydromethysticin
Methysticin
7,8-Dihydromethysticin
Yangonin
酰基脲类
Acecarbromal
Apronal (apronalide)
Bromisoval
Carbromal
Capuride
Ectylurea
神经甾体类
Acebrochol
Allopregnanolone (brexanolone)
Alfadolone
Alfaxalone
3α-Androstanediol
Androstenol
Androsterone
Certain anabolic-androgenic steroids
胆固醇
DHDOC
3α-DHP
5α-DHP
5β-DHP
DHT
Etiocholanolone
Ganaxolone
Hydroxydione
Minaxolone
ORG-20599
ORG-21465
P1-185
Posovolone
Pregnanolone (eltanolone)
孕酮
Renanolone
SAGE-105
SAGE-324
SAGE-516
SAGE-689
SAGE-872
睾酮
四氢脱氧皮质酮
Zuranolone
非苯二氮䓬类
吡唑并嘧啶类 : 地伐普隆
法西普隆
茚地普隆
罗利普隆
奥西普隆
帕那普隆
他尼普隆
扎来普隆
其它 : 阿哌普隆
CGS-8216
CGS-9896
CGS-13767
CGS-20625
CL-218,872
CP-615,003
CTP-354
ELB-139
GBLD-345
伊匹妥英
JM-1232
L-838,417
利瑞喹尼
NS-2664
NS-2710
NS-11394
哌夸林
ROD-188
RWJ-51204
SB-205,384
SX-3228
TGSC01AA
TP-003
TPA-023
TP-13
U-89843A
U-90042
维喹啉
Y-23684
酚类 戊二酰亚胺类 吡唑并吡啶类 喹唑啉酮类 挥发物/气体 其他/未分类
未分类的苯二氮䓬位点正向调节剂: α-蒎烯
MRK-409
TCS-1105
TCS-1205
参见: 受体/信号调节剂 • GABA受体调节剂 • Template:GABA代谢和运输调节剂GABA代谢和运输调节剂
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