昂丹司琼
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| 臨床資料 | |
|---|---|
| 商品名 | Zofran, Ondisolv, others |
| AHFS/Drugs.com | Monograph |
| MedlinePlus | a601209 |
| 懷孕分級 |
|
| 给药途径 | by mouth, rectal, IV, IM |
| ATC碼 | |
| 法律規範狀態 | |
| 法律規範 |
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| 藥物動力學數據 | |
| 生物利用度 | ~60% |
| 血漿蛋白結合率 | 70%-76% |
| 药物代谢 | Liver (CYP3A4, CYP1A2, CYP2D6) |
| 生物半衰期 | 5.7 hours |
| 排泄途徑 | Kidney |
| 识别信息 | |
| |
| CAS号 | 99614-02-5  |
| PubChem CID | |
| IUPHAR/BPS | |
| DrugBank | |
| ChemSpider | |
| UNII | |
| KEGG | |
| ChEMBL | |
| CompTox Dashboard (EPA) | |
| ECHA InfoCard | 100.110.918 |
| 化学信息 | |
| 化学式 | C18H19N3O |
| 摩尔质量 | 293.4 g/mol |
| 3D模型（JSmol） | |
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昂丹司瓊（Ondansetron），常見商品名 Zofran，是一種用於減少手術、化療、放射治療後，惡心嘔吐的藥物[1]。亦可用於治療腸胃炎[2][3]。但對於動暈症幾乎無治療效果[4]。本品可經口服給藥，也可以肌肉注射或靜脈注射使用[1]。
常見的副作用包括腹瀉、頭痛、嗜睡和皮膚搔癢[1]。嚴重的話可能誘發QT波延長或是全身性過敏反應[1]。妊娠期間用藥似為安全，但相關證據仍不足夠[1]。此藥物是一種高專一性的血清素5-HT3受體拮抗劑[1]，並不會針對多巴胺受體或蕈鹼類受器[5]。
昂丹司瓊在1990年首次被作為藥物使用[6]。本品列名於世界卫生组织基本药物标准清单，該清單紀錄了一般衛生體系最需要的藥物[7]。目前已是學名藥[1]。其於開發中國家的每劑注射劑型批發價約介於0.1到0.76美金[8]。在美國，每顆藥物大約花費1.37美金[1]。
參考文獻
- ^ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 Ondansetron Hydrochloride. The American Society of Health-System Pharmacists. [February 11, 2017]. （原始内容存档于2016-05-03）.
- ^ Schnadower, D; Finkelstein, Y; Freedman, SB. Ondansetron and probiotics in the management of pediatric acute gastroenteritis in developed countries.. Current Opinion in Gastroenterology. January 2015, 31 (1): 1–6. PMID 25333367. doi:10.1097/mog.0000000000000132.
- ^ Freedman, SB; Ali, S; Oleszczuk, M; Gouin, S; Hartling, L. Treatment of acute gastroenteritis in children: an overview of systematic reviews of interventions commonly used in developed countries.. Evidence-based child health : a Cochrane review journal. July 2013, 8 (4): 1123–37. PMID 23877938. doi:10.1002/ebch.1932.
- ^ Sutton, M; Mounsey, AL; Russell, RG. FPIN's Clinical Inquiries. Treatment of motion sickness.. American Family Physician. 15 July 2012, 86 (2): 192–5. PMID 22962932.
- ^ Miloro, ed. by Michael. Peterson's principles of oral and maxillofacial surgery. 3rd. Shelton, CT: People's Medical Pub. House-USA. 2012: 86 [2018-02-03]. ISBN 978-1-60795-111-7. （原始内容存档于2016-02-01）.
- ^ Sneader, Walter. Drug discovery: a history Rev. and updated. Chichester: Wiley. 2005: 217 [2018-02-03]. ISBN 978-0-471-89979-2. （原始内容存档于2016-02-01）.
- ^ WHO Model List of Essential Medicines (19th List) (PDF). World Health Organization. April 2015 [8 December 2016]. （原始内容存档 (PDF)于2016-12-13）.
- ^ Ondansetron. International Drug Price Indicator Guide. [26 January 2016]. （原始内容存档于2017-05-10）.
外部連結
Template:5-HT3 antagonists
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