VER-3323
Izvor: Wikipedija
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| (IUPAC) ime | |||
|---|---|---|---|
| (2S)-1-(6-bromo-2,3-dihidroindol-1-il)propan-2-amin | |||
| Klinički podaci | |||
| Identifikatori | |||
| ATC kod | ? | ||
| PubChem[1][2] | 6604042 | ||
| Hemijski podaci | |||
| Formula | C11H15BrN2 | ||
| Mol. masa | 255,154 g/mol | ||
| SMILES | eMolekuli & PubHem | ||
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| Farmakoinformacioni podaci | |||
| Trudnoća | ? | ||
| Pravni status | |||
VER-3323 je lek koji deluje kao selektivni agonist 5-HT2B i 5-HT2C serotoninskih receptora, sa umerenom selektivnošću za 5-HT2C, i relativno niskim afinitetom za 5-HT2A. U životinjskim studijama je utvrđeno da je on potentan anoreksik .[3][4][5][6]
- ↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519.
- ↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
- ↑ Knight AR, Misra A, Quirk K, Benwell K, Revell D, Kennett G, Bickerdike M (August 2004). „Pharmacological characterisation of the agonist radioligand binding site of 5-HT(2A), 5-HT(2B) and 5-HT(2C) receptors”. Naunyn-Schmiedeberg's Archives of Pharmacology 370 (2): 114–23. DOI:10.1007/s00210-004-0951-4. PMID 15322733.
- ↑ Halford JC, Harrold JA, Lawton CL, Blundell JE (March 2005). „Serotonin (5-HT) drugs: effects on appetite expression and use for the treatment of obesity”. Current Drug Targets 6 (2): 201–13. PMID 15777190.
- ↑ Schuhler S, Clark A, Joseph W, Patel A, Lehnen K, Stratford E, Horan TL, Fone KC, Ebling FJ (May 2005). „Involvement of 5-HT receptors in the regulation of food intake in Siberian hamsters”. Journal of Neuroendocrinology 17 (5): 276–85. DOI:10.1111/j.1365-2826.2005.01303.x. PMID 15869562.
- ↑ Song J, Hanniford D, Doucette C, Graham E, Poole MF, Ting A, Sherf B, Harrington J, Brunden K, Stricker-Krongrad A (December 2005). „Development of homogeneous high-affinity agonist binding assays for 5-HT2 receptor subtypes”. Assay and Drug Development Technologies 3 (6): 649–59. DOI:10.1089/adt.2005.3.649. PMID 16438660.
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