EGIS-12,233
Izvor: Wikipedija
(IUPAC) ime | |||
---|---|---|---|
5,7-dihloro-3-[4-[4-(4-hlorofenil)piperazin-1-il]butil]-3-etil-indolin-2-on | |||
Klinički podaci | |||
Identifikatori | |||
ATC kod | nije dodeljen | ||
PubChem[1][2] | 11525867 | ||
Hemijski podaci | |||
Formula | C24H28Cl3N3O | ||
Mol. masa | 480,856 g/mol | ||
SMILES | eMolekuli & PubHem | ||
| |||
Farmakoinformacioni podaci | |||
Trudnoća | ? | ||
Pravni status |
EGIS-12,233 je lek koji se koristi u naučnim istraživanjima. On deluje kao potentan i selektivan antagonist za 5-HT6 i 5-HT7 serotoninske receptore, sa znatnom selektivnošću u odnosu na druge receptore.[3] On povećava otpuštanje dopaminu tkivu puža uveta, iz čega sledi da 5-HT6 i 5-HT7 receptori učestvuju u regulaciji slušnog sistema.[4]
- ↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519.
- ↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
- ↑ Volk, B; Barkóczy, J; Hegedus, E; Udvari, S; Gacsályi, I; Mezei, T; Pallagi, K; Kompagne, H i dr.. (2008). „(Phenylpiperazinyl-butyl)oxindoles as selective 5-HT7 receptor antagonists”. Journal of Medical Chemistry 51 (8): 2522–32. DOI:10.1021/jm070279v. PMID 18361484.
- ↑ Doleviczényi, Z; Vizi, ES; Gacsályi, I; Pallagi, K; Volk, B; Hársing Jr, LG; Halmos, G; Lendvai, B i dr.. (2008). „5-HT6/7 receptor antagonists facilitate dopamine release in the cochlea via a GABAergic disinhibitory mechanism”. Neurochemical research 33 (11): 2364–72. DOI:10.1007/s11064-008-9796-4. PMID 18663573.
Text is available under the CC BY-SA 4.0 license; additional terms may apply.
Images, videos and audio are available under their respective licenses.