SGK3

SGK3
Identifiers
Aliases	SGK3, CISK, SGK2, SGKL, serum/glucocorticoid regulated kinase family member 3
External IDs	OMIM: 607591; MGI: 2182368; HomoloGene: 56582; GeneCards: SGK3; OMA:SGK3 - orthologs
Gene location (Human)
Chr.	Chromosome 8 (human)
End	66,862,022 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	9,971,070 bp
RNA expression pattern
	Top expressed in
	retinal pigment epithelium; ; corpus callosum; ; inferior ganglion of vagus nerve; ; mucosa of ileum; ; subthalamic nucleus; ; skin of arm; ; pars reticulata; ; jejunal mucosa; ; medulla oblongata; ; skin of hip;
	Top expressed in
	vestibular membrane of cochlear duct; ; retinal pigment epithelium; ; Epithelium of choroid plexus; ; molar; ; gastrula; ; granulocyte; ; hair follicle; ; endothelial cell of lymphatic vessel; ; cornea; ; stria vascularis;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity; protein kinase activity; nucleotide binding; sodium channel regulator activity; calcium channel regulator activity; kinase activity; potassium channel regulator activity; protein binding; phosphatidylinositol binding; chloride channel regulator activity; ATP binding; protein serine/threonine kinase activity;
Cellular component	recycling endosome; cytosol; endosome; early endosome; cytoplasmic vesicle;
Biological process	regulation of apoptotic process; intracellular signal transduction; regulation of cell migration; positive regulation of transporter activity; phosphorylation; protein phosphorylation; ion transmembrane transport; regulation of cell population proliferation; peptidyl-serine phosphorylation; regulation of DNA-binding transcription factor activity; regulation of cell growth; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand;
	Sources:Amigo / QuickGO
Orthologs
	23678
	170755
	ENSG00000104205
	ENSMUSG00000025915
	Q96BR1
	Q9ERE3
	NM_170709; NM_001033578; NM_013257
	NM_001037759; NM_133220; NM_177547
	NP_001191102; NP_001028750; NP_037389; NP_733827
	NP_001032848; NP_573483; NP_808215
	Wikidata
View/Edit Human	View/Edit Mouse

Serine/threonine-protein kinase Sgk3 is an enzyme that in humans is encoded by the SGK3 gene.^[5]^[6]^[7]

Function

This gene is a member of the serine/threonine protein kinase family and encodes a phosphoprotein with a PX (phox homology) domain. The protein phosphorylates several target proteins and has a role in neutral amino acid transport and activation of potassium and chloride channels. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.^[7]

In melanocytic cells SGK3 gene expression may be regulated by MITF.^[8]

Interactions

SGK3 has been shown to interact with GSK3B.^[9]

References

Lang F, Cohen P (2002). "Regulation and physiological roles of serum- and glucocorticoid-induced protein kinase isoforms". Sci. STKE. 2001 (108): RE17. doi:10.1126/stke.2001.108.re17. PMID 11707620. S2CID 25927734.
Ali A, Hoeflich KP, Woodgett JR (2002). "Glycogen synthase kinase-3: properties, functions, and regulation". Chem. Rev. 101 (8): 2527–40. doi:10.1021/cr000110o. PMID 11749387.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Fang X, Yu SX, Lu Y, Bast RC, Woodgett JR, Mills GB (2000). "Phosphorylation and inactivation of glycogen synthase kinase 3 by protein kinase A". Proc. Natl. Acad. Sci. U.S.A. 97 (22): 11960–5. Bibcode:2000PNAS...9711960F. doi:10.1073/pnas.220413597. PMC 17277. PMID 11035810.
Xu J, Liu D, Gill G, Songyang Z (2001). "Regulation of cytokine-independent survival kinase (CISK) by the Phox homology domain and phosphoinositides". J. Cell Biol. 154 (4): 699–705. doi:10.1083/jcb.200105089. PMC 2196448. PMID 11514587.
Yun CC, Chen Y, Lang F (2002). "Glucocorticoid activation of Na(+)/H(+) exchanger isoform 3 revisited. The roles of SGK1 and NHERF2". J. Biol. Chem. 277 (10): 7676–83. doi:10.1074/jbc.M107768200. PMID 11751930.
Fang X, Yu S, Tanyi JL, Lu Y, Woodgett JR, Mills GB (2002). "Convergence of Multiple Signaling Cascades at Glycogen Synthase Kinase 3: Edg Receptor-Mediated Phosphorylation and Inactivation by Lysophosphatidic Acid through a Protein Kinase C-Dependent Intracellular Pathway". Mol. Cell. Biol. 22 (7): 2099–110. doi:10.1128/MCB.22.7.2099-2110.2002. PMC 133668. PMID 11884598.
Dai F, Yu L, He H, Chen Y, Yu J, Yang Y, Xu Y, Ling W, Zhao S (2002). "Human serum and glucocorticoid-inducible kinase-like kinase (SGKL) phosphorylates glycogen syntheses kinase 3 beta (GSK-3beta) at serine-9 through direct interaction". Biochem. Biophys. Res. Commun. 293 (4): 1191–6. doi:10.1016/S0006-291X(02)00349-2. PMID 12054501.
Brickley DR, Mikosz CA, Hagan CR, Conzen SD (2003). "Ubiquitin modification of serum and glucocorticoid-induced protein kinase-1 (SGK-1)". J. Biol. Chem. 277 (45): 43064–70. doi:10.1074/jbc.M207604200. PMID 12218062.
Gamper N, Fillon S, Feng Y, Friedrich B, Lang PA, Henke G, Huber SM, Kobayashi T, Cohen P, Lang F (2003). "K+ channel activation by all three isoforms of serum- and glucocorticoid-dependent protein kinase SGK". Pflügers Arch. 445 (1): 60–6. doi:10.1007/s00424-002-0873-2. PMID 12397388. S2CID 21073737.
Henke G, Setiawan I, Böhmer C, Lang F (2003). "Activation of Na+/K+-ATPase by the serum and glucocorticoid-dependent kinase isoforms". Kidney Blood Press. Res. 25 (6): 370–4. doi:10.1159/000068699. PMID 12590200. S2CID 30241243.
Friedrich B, Feng Y, Cohen P, Risler T, Vandewalle A, Bröer S, Wang J, Pearce D, Lang F (2003). "The serine/threonine kinases SGK2 and SGK3 are potent stimulators of the epithelial Na+ channel alpha,beta,gamma-ENaC". Pflügers Arch. 445 (6): 693–6. doi:10.1007/s00424-002-0993-8. PMID 12632189. S2CID 32511608.
Embark HM, Böhmer C, Vallon V, Luft F, Lang F (2003). "Regulation of KCNE1-dependent K(+) current by the serum and glucocorticoid-inducible kinase (SGK) isoforms". Pflügers Arch. 445 (5): 601–6. doi:10.1007/s00424-002-0982-y. PMID 12634932. S2CID 22981271.
Nilsen T, Slagsvold T, Skjerpen CS, Brech A, Stenmark H, Olsnes S (2004). "Peroxisomal targeting as a tool for assaying protein-protein interactions in the living cell: cytokine-independent survival kinase (CISK) binds PDK-1 in vivo in a phosphorylation-dependent manner". J. Biol. Chem. 279 (6): 4794–801. doi:10.1074/jbc.M309653200. PMID 14604990.

v t e Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Diffusion-limited enzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) EC7 Translocases (list)

SGK3

Function

Interactions

References

Further reading

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