PRKAG3
Identifiers
Aliases	PRKAG3, AMPKG3, protein kinase AMP-activated non-catalytic subunit gamma 3, SMGMQTL
External IDs	MGI: 1891343; HomoloGene: 23006; GeneCards: PRKAG3; OMA:PRKAG3 - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2q35 Start 218,822,383 bp[1] End 218,832,086 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1|1 C4 Start 74,778,081 bp[2] End 74,788,380 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in muscle of thigh gastrocnemius muscle tibialis anterior muscle skeletal muscle tissue Skeletal muscle tissue of rectus abdominis quadriceps femoris muscle vastus lateralis muscle biceps brachii testicle deltoid muscle Top expressed in medial head of gastrocnemius muscle triceps brachii muscle vastus lateralis muscle knee joint tibialis anterior muscle skeletal muscle tissue muscle of thigh sternocleidomastoid muscle temporal muscle ankle More reference expression data BioGPS n/a
Gene ontology Molecular function nucleotide binding AMP-activated protein kinase activity ATP binding protein kinase binding adenyl ribonucleotide binding Cellular component cytosol nucleotide-activated protein kinase complex nucleoplasm extracellular space Biological process intracellular signal transduction lipid metabolism fatty acid metabolic process protein phosphorylation fatty acid biosynthetic process glycogen biosynthetic process macroautophagy regulation of signal transduction by p53 class mediator regulation of macroautophagy glycolytic process response to muscle activity involved in regulation of muscle adaptation regulation of protein serine/threonine kinase activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 53632 241113 Ensembl ENSG00000115592 ENSMUSG00000006542 UniProt Q9UGI9 Q8BGM7 RefSeq (mRNA) NM_017431 NM_153744 NM_153745 RefSeq (protein) NP_059127 NP_714966 Location (UCSC) Chr 2: 218.82 – 218.83 Mb Chr 1: 74.78 – 74.79 Mb PubMed search [3] [4]
Wikidata
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5'-AMP-activated protein kinase subunit gamma-3 is an enzyme that in humans is encoded by the PRKAG3 gene.^[5][6]

Function

The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit is one of the gamma regulatory subunits of AMPK. It is dominantly expressed in skeletal muscle. Studies of the pig counterpart suggest that this subunit may play a key role in the regulation of energy metabolism in skeletal muscle.^[6]