RPS6KA3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4D9T, 4D9U, 4JG6, 4JG7, 4JG8, 4NUS, 4NW5, 4NW6, 5D9K, 5D9L
Identifiers
Aliases	RPS6KA3, CLS, HU-3, ISPK-1, MAPKAPK1B, MRX19, RSK, RSK2, S6K-alpha3, p90-RSK2, pp90RSK2, ribosomal protein S6 kinase A3, XLID19
External IDs	OMIM: 300075; MGI: 104557; HomoloGene: 37940; GeneCards: RPS6KA3; OMA:RPS6KA3 - orthologs
Gene location (Human) Chr. X chromosome (human)[1] Band Xp22.12 Start 20,149,911 bp[1] End 20,267,519 bp[1]
Gene location (Mouse) Chr. X chromosome (mouse)[2] Band X F4|X 73.27 cM Start 157,993,303 bp[2] End 158,151,240 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in cartilage tissue mucosa of sigmoid colon biceps brachii triceps brachii muscle islet of Langerhans deltoid muscle gastrocnemius muscle glutes quadriceps femoris muscle Skeletal muscle tissue of biceps brachii Top expressed in trigeminal ganglion body of femur left colon white adipose tissue lumbar spinal ganglion Paneth cell left lung lobe genital tubercle mandibular prominence gastrula More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity protein kinase activity nucleotide binding metal ion binding cysteine-type endopeptidase inhibitor activity involved in apoptotic process protein binding ATP binding protein kinase binding magnesium ion binding kinase activity protein serine/threonine kinase activity ribosomal protein S6 kinase activity Cellular component cytoplasm cytosol nucleoplasm nucleus Biological process skeletal system development negative regulation of cysteine-type endopeptidase activity involved in apoptotic process regulation of translation in response to stress intracellular signal transduction phosphorylation negative regulation of apoptotic process protein phosphorylation central nervous system development positive regulation of cell growth response to lipopolysaccharide positive regulation of cell differentiation cell cycle regulation of DNA-templated transcription in response to stress signal transduction positive regulation of transcription by RNA polymerase II toll-like receptor signaling pathway apoptotic process peptidyl-serine phosphorylation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6197 110651 Ensembl ENSG00000177189 ENSMUSG00000031309 UniProt P51812 P18654 RefSeq (mRNA) NM_004586 NM_148945 NM_001346675 RefSeq (protein) NP_004577 NP_001333604 NP_683747 Location (UCSC) Chr X: 20.15 – 20.27 Mb Chr X: 157.99 – 158.15 Mb PubMed search [3] [4]
Wikidata
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protein S6 kinase, 90kDa, polypeptide 3, also s RPS6KA3, is an enzyme that in humans is encoded by the RPS6KA3 gene.^[5][6]

Function

This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation.^[5]

Clinical significance

Mutations in this gene have been associated with Coffin–Lowry syndrome (CLS).^[7]

Interactions

RPS6KA3 has been shown to interact with CREB-binding protein,^[8] MAPK1^[9][10] and PEA15.^[11]