Protein-coding gene in the species Homo sapiens
Guanine nucleotide-binding protein subunit beta-5 is a protein that in humans is encoded by the GNB5 gene.[5] Alternatively spliced transcript variants encoding different isoforms exist.[6]
Function
Heterotrimeric guanine nucleotide-binding proteins (G proteins), which integrate signals between receptors and effector proteins, are composed of an alpha, a beta, and a gamma subunit. These subunits are encoded by families of related genes. This gene encodes a beta subunit. Beta subunits are important regulators of alpha subunits, as well as of certain signal transduction receptors and effectors.[6]
GNB5 has been shown to differentially control RGS protein stability and membrane anchor binding, and therefore is involved in the control of complex neuronal G protein signaling pathways.[7]
Interactions
GNB5 has been shown to interact with: