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蝙蝠冠狀病毒HKU10

蝙蝠冠狀病毒HKU10
病毒分類 编辑
(未分级) 病毒 Virus
域: 核糖病毒域 Riboviria
界: 正核糖病毒界 Orthornavirae
门: 小核糖病毒门 Pisuviricota
纲: 小南嵌套病毒纲 Pisoniviricetes
目: 套式病毒目 Nidovirales
科: 冠状病毒科 Coronaviridae
属: 甲型冠狀病毒屬 Alphacoronavirus
种:
蝙蝠冠狀病毒HKU10 Rousettus bat coronavirus HKU10

蝙蝠冠狀病毒HKU10Rousettus bat coronavirus HKU10、BatCoV HKU10)是甲型冠狀病毒屬的一種病毒,於2007年在中國廣東棕果蝠體內發現[1],名為果蝠冠狀病毒HKU10(Ro-BatCoV),隨後又在香港小蹄蝠體內被發現,名為蹄蝠冠狀病毒HKU10(Hi-BatCoV HKU10)[2]

基因組

蝙蝠冠狀病毒HKU10的基因組長約28400nt,除冠狀病毒皆有的複製酶和刺突蛋白(S)、膜蛋白(M)、外膜蛋白(E)與衣殼蛋白(N)等四種結構蛋白外,此病毒在刺突蛋白與外膜蛋白的基因有一開放閱讀框,編碼一輔助蛋白NS3,另外在基因組的最3端(衣殼蛋白基因的下游)還有三個開放閱讀框,編碼NS7a、NS7b與NS7c等三個輔助蛋白。果蝠冠狀病毒HKU10與蹄蝠冠狀病毒HKU10的序列相似度為93%–97%,但兩者的刺突蛋白序列差異較大,胺基酸序列的相似度僅有60.5%[2]

參考文獻

  1. ^ Woo, P. C. Y.; Wang, M.; Lau, S. K. P.; Xu, H.; Poon, R. W. S.; Guo, R.; Wong, B. H. L.; Gao, K.; Tsoi, H.-w.; Huang, Y.; Li, K. S. M.; Lam, C. S. F.; Chan, K.-h.; Zheng, B.-j.; Yuen, K.-y. Comparative Analysis of Twelve Genomes of Three Novel Group 2c and Group 2d Coronaviruses Reveals Unique Group and Subgroup Features. Journal of Virology. 2006, 81 (4): 1574–1585. ISSN 0022-538X. doi:10.1128/JVI.02182-06. 
  2. ^ 2.0 2.1 Lau, S. K. P.; Li, K. S. M.; Tsang, A. K. L.; Shek, C.-T.; Wang, M.; Choi, G. K. Y.; Guo, R.; Wong, B. H. L.; Poon, R. W. S.; Lam, C. S. F.; Wang, S. Y. H.; Fan, R. Y. Y.; Chan, K.-H.; Zheng, B.-J.; Woo, P. C. Y.; Yuen, K.-Y. Recent Transmission of a Novel Alphacoronavirus, Bat Coronavirus HKU10, from Leschenault's Rousettes to Pomona Leaf-Nosed Bats: First Evidence of Interspecies Transmission of Coronavirus between Bats of Different Suborders. Journal of Virology. 2012, 86 (21): 11906–11918. ISSN 0022-538X. doi:10.1128/JVI.01305-12. 
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蝙蝠冠狀病毒HKU10
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