葡萄糖-6-磷酸脱氢酶
| 葡萄糖-6-磷酸脱氢酶 | |||||||||
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| 葡萄糖-6-磷酸脱氢酶结构（PDB 1qki） | |||||||||
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| 识别码 | |||||||||
| EC編號 | 1.1.1.49 | ||||||||
| CAS号 | 9001-40-5 | ||||||||
| 数据库 | |||||||||
| IntEnz | IntEnz浏览 | ||||||||
| BRENDA | BRENDA入口 | ||||||||
| ExPASy | NiceZyme浏览 | ||||||||
| KEGG | KEGG入口 | ||||||||
| MetaCyc | 代谢路径 | ||||||||
| PRIAM | 概述 | ||||||||
| PDB | RCSB PDB PDBj PDBe PDBsum | ||||||||
| 基因本体 | AmiGO / EGO | ||||||||
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葡萄糖-6-磷酸脱氢酶（英語：glucose-6-phosphate dehydrogenase，EC 1.1.1.49 （页面存档备份，存于互联网档案馆））是一种以NAD+或NADP+为受体、作用于供体CH-OH基团上的氧化还原酶。这种酶能催化以下酶促反应：
- D-葡萄糖-6-磷酸 + NADP+ D-葡萄糖酸-1,5-内酯-6-磷酸 + NADPH + H+
葡萄糖-6-磷酸脱氢酶主要参与磷酸戊糖途径，也能缓慢地作用在β-D-葡萄糖等其他糖类上。这种酶可由其底物葡萄糖-6-磷酸激活。
葡萄糖-6-磷酸脱氢酶存在于众多生物细胞内，高等植物拥有数种葡萄糖-6-磷酸脱氢酶的蛋白异构体（protein isoform），它们分布于细胞质基质、和过氧化物酶体等细胞结构中。[1]如果人类表达葡萄糖-6-磷酸脱氢酶的基因有缺陷，将会导致葡萄糖-6-磷酸脱氢酶缺乏症，进而引发非免疫性溶血性贫血。
參考資料
[编辑]- ^ Corpas FJ; et al. A dehydrogenase-mediated recycling system of NADPH in plant peroxisomes. Biochem. J. 1998, 330 (7): 777–784.
参考文献
[编辑]- Vulliamy T, Beutler E, Luzzatto L. Variants of glucose-6-phosphate dehydrogenase are due to missense mutations spread throughout the coding region of the gene.. Hum. Mutat. 1993, 2 (3): 159–67. PMID 8364584. doi:10.1002/humu.1380020302.
- Mason PJ. New insights into G6PD deficiency.. Br. J. Haematol. 1996, 94 (4): 585–91. PMID 8826878.
- Wajcman H, Galactéros F. [Glucose 6-phosphate dehydrogenase deficiency: a protection against malaria and a risk for hemolytic accidents]. C. R. Biol. 2004, 327 (8): 711–20. PMID 15506519.
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