For faster navigation, this Iframe is preloading the Wikiwand page for EC編號.

EC編號

EC編號EC號酶學委員會英语Enzyme Commission所製作的一套編號分類法,是以每種酶所催化化學反應為分類基礎[1]。這套分類法亦同時會為各種酶給予一個建議的名稱,所以亦稱為酶學委員會命名法

历史

於1955年在布魯塞爾舉行的國際生物化學大會,設立了酶學委員會,這個酶命名法才開始發展,初版於1961年發行。於1992年在國際生物化學與分子生物學大會中發行的第六版中,已包含有3196種不同的酶。

编号规则

每一個酶的編號都以字母「EC」起頭,接著以四個號碼來表示,這些號碼代表逐步更細緻的為酶作出分類。就如三肽胺基 蛋白酶的編號為EC3.4.11.4,當中的「EC3」是指水解酶(即以來將分子分解的酶);「EC3.4」是那些與肽鍵產生作用的水解酶;「EC3.4.11」是單指那些從多胜肽中分開胺基末端的水解酶;「EC3.4.11.4」則是從三肽中分開胺基末端的水解酶。

嚴格來說,EC編號並非指定不同種類的酶,而是指定催化作用。如不同的酶(在不同的生物中)催化同一的各應,它們均會編有同一的編號。

顶层的编组

顶层的EC编号[2]
組別 被催化的化学反应 典型反应 酶的例子(俗名)
EC 1英语List of EC numbers (EC 1)
氧化還原酶
催化氧化/還原作用;將氫及氧原子,或電子從一物質轉移至另一物質。 AH + B → A + BH (還原)
A + O → AO (氧化)
脫氫酶氧化酶
EC 2英语List of EC numbers (EC 2)
轉移酶
官能團從一個物質轉移至另一物質。轉移的基團可以是甲基、酰基、氨基或磷酸。 AB + C → A + BC 轉氨酶激酶
EC 3英语List of EC numbers (EC 3)
水解酶
底物水解來生成兩個化合物。 AB + H2O → AOH + BH 脂肪酶澱粉酶蛋白酶
EC 4英语List of EC numbers (EC 4)
裂合酶
非水解的增加或移走底物的某些基團。C-C、C-N、C-O 或 C-S 等共價鍵可能被分裂。 RCOCOOH → RCOH + CO2
[X-A-B-Y] → [A=B + X-Y]
Decarboxylase
EC 5英语List of EC numbers (EC 5)
異構酶
重整分子內的排列,例如將分子異構化 ABC → BCA 異構酶變位酶
EC 6英语List of EC numbers (EC 6)
連接酶
合成新的C-O、C-S、C-N 或 C-C 等共價鍵,並同時分解三磷酸腺苷(ATP)來把兩個分子結合。 X + Y+ ATP → XY + ADP + Pi 合成酶

参考文献

  1. ^ Webb EC. Enzyme nomenclature 1992: recommendations of the Nomenclature Committee of the International Union of Biochemistry and Molecular Biology on the nomenclature and classification of enzymes. San Diego, CA: Published for the International Union of Biochemistry and Molecular Biology by Academic Press. 1992. ISBN 0-12-227164-5. (原始内容存档于2017-09-05). 
  2. ^ Moss GP. Recommendations of the Nomenclature Committee. International Union of Biochemistry and Molecular Biology on the Nomenclature and Classification of Enzymes by the Reactions they Catalyse. [2006-03-14]. (原始内容存档于2017-09-05). 

外部链接

参见

{{bottomLinkPreText}} {{bottomLinkText}}
EC編號
Listen to this article

This browser is not supported by Wikiwand :(
Wikiwand requires a browser with modern capabilities in order to provide you with the best reading experience.
Please download and use one of the following browsers:

This article was just edited, click to reload
This article has been deleted on Wikipedia (Why?)

Back to homepage

Please click Add in the dialog above
Please click Allow in the top-left corner,
then click Install Now in the dialog
Please click Open in the download dialog,
then click Install
Please click the "Downloads" icon in the Safari toolbar, open the first download in the list,
then click Install
{{::$root.activation.text}}

Install Wikiwand

Install on Chrome Install on Firefox
Don't forget to rate us

Tell your friends about Wikiwand!

Gmail Facebook Twitter Link

Enjoying Wikiwand?

Tell your friends and spread the love:
Share on Gmail Share on Facebook Share on Twitter Share on Buffer

Our magic isn't perfect

You can help our automatic cover photo selection by reporting an unsuitable photo.

This photo is visually disturbing This photo is not a good choice

Thank you for helping!


Your input will affect cover photo selection, along with input from other users.

X

Get ready for Wikiwand 2.0 🎉! the new version arrives on September 1st! Don't want to wait?