地诺帕明
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| 臨床資料 | |
|---|---|
| AHFS/Drugs.com | 国际药品名称 |
| 给药途径 | 口服（片剂） |
| ATC碼 |
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| 法律規範狀態 | |
| 法律規範 |
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| 识别信息 | |
| |
| CAS号 | 71771-90-9 |
| PubChem CID | |
| IUPHAR/BPS | |
| ChemSpider | |
| UNII | |
| KEGG | |
| ChEMBL | |
| CompTox Dashboard (EPA) | |
| ECHA InfoCard | 100.163.233 |
| 化学信息 | |
| 化学式 | C18H23NO4 |
| 摩尔质量 | 317.39 g·mol−1 |
| 3D模型（JSmol） | |
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地诺帕明（INN：denopamine）是一种强心药，它可充当β1肾上腺素受体激动剂。[1]它用于治疗心绞痛，[2]也可能在治疗充血性心力衰竭[3] 和清除肺水肿方面具有潜在用途。[4]它在日本以商品名Kalgut（カルグート）上市，有5毫克和10毫克片剂以及5%细颗粒剂可供选择。[5]
参考资料
[编辑]- ^ Ishide T. Denopamine, a selective beta1-receptor agonist and a new coronary vasodilator. Current Medical Research and Opinion. 2002, 18 (7): 407–13. PMID 12487507. S2CID 25048757. doi:10.1185/030079902125001119.
- ^ Nakajima D, Negoro N, Nakaboh A, Nakakoji T, Hoshiga M, Nariyama J, et al. Effectiveness of low dose denopamine, a beta1-adrenoceptor agonist, in a patient with vasospastic angina refractory to intensive medical treatment. International Journal of Cardiology. April 2006, 108 (2): 281–3. PMID 15913812. doi:10.1016/j.ijcard.2005.03.012.
- ^ Nishio R, Matsumori A, Shioi T, Wang W, Yamada T, Ono K, Sasayama S. Denopamine, a beta1-adrenergic agonist, prolongs survival in a murine model of congestive heart failure induced by viral myocarditis: suppression of tumor necrosis factor-alpha production in the heart. Journal of the American College of Cardiology. September 1998, 32 (3): 808–15. PMID 9741531. doi:10.1016/S0735-1097(98)00314-3. hdl:2433/181223
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- ^ Sakuma T, Hida M, Nambu Y, Osanai K, Toga H, Takahashi K, et al. Beta1-adrenergic agonist is a potent stimulator of alveolar fluid clearance in hyperoxic rat lungs. Japanese Journal of Pharmacology. February 2001, 85 (2): 161–6. PMID 11286398. doi:10.1254/jjp.85.161 .
- ^ Kalgut (denopamine) Tablets 5, 10 mg; Fine granules 5%. Full Prescribing Information (PDF). Mitsubishi Tanabe Pharma Corporation. [6 March 2016]. （原始内容存档 (PDF)于2024-03-31） （Japanese）.
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