表雄酮
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| 临床资料 | |
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| ATC码 |
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| 识别信息 | |
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| CAS号 | 481-29-8  |
| PubChem CID | |
| ChemSpider | |
| UNII | |
| ChEBI | |
| ChEMBL | |
| CompTox Dashboard (EPA) | |
| ECHA InfoCard | 100.006.877 |
| 化学信息 | |
| 化学式 | C19H30O2 |
| 摩尔质量 | 290.440 g/mol |
| 3D模型（JSmol） | |
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表雄酮（英语：Epiandrosterone）或称为异雄酮（英语：isoandrosterone）[1][2]是一种甾体激素，拥有较弱的雄激素活性，是睾酮和双氢睾酮（DHT）的代谢产物，在1931年由阿道夫·布特南特和库尔特·切尔宁首次分离。他们蒸馏了17000升的男性尿液，从中得到50毫克的雄酮结晶（很可能是混合了的α/β异构体），并发现其和雌酮有着相似的化学结构。
大部分哺乳动物包括猪都能合成表雄酮[3]，在体内可由5α还原酶催化肾上腺激素DHEA而来[4][5][6][7]，另外也可由3β-雄烷二醇经17β-羟基类固醇脱氢酶催化或雄烷二酮经3β-羟基类固醇脱氢酶催化而来。
参见
[编辑]参考文献
[编辑]- ^ Samuel H. Yalkowsky; Yan He; Parijat Jain. Handbook of Aqueous Solubility Data, Second Edition. CRC Press. 19 April 2016: 1209–. ISBN 978-1-4398-0246-5.
- ^ Natural Products. Krishna Prakashan Media. 2006: 298–. ISBN 978-81-87224-85-3.
- ^ Raeside JI, Renaud RL, Marshall DE. Identification of 5 alpha-androstane-3 beta,17 beta-diol and 3 beta-hydroxy-5 alpha-androstan-17-one sulfates as quantitatively significant secretory products of porcine Leydig cells and their presence in testicular venous blood. J Steroid Biochem Mol Biol. 42(1):113-20, 1992
- ^ Callies F, Arlt W, Siekmann L, Hübler D, Bidlingmaier F, Allolio B. Influence of oral dehydroepiandrosterone (DHEA) on urinary steroid metabolites in males and females. Steroids. 65(2):98-102, 2000
- ^ Labrie F, Cusan L, Gomez JL, Martel C, Bérubé R, Bélanger P, Chaussade V, Deloche C, Leclaire J. Changes in serum DHEA and eleven of its metabolites during 12-month percutaneous administration of DHEA. J Steroid Biochem Mol Biol. 2008 May;110(1-2):1-9
- ^ Daniël Henri van de Kerkhof. Steroid profiling in doping analysis. [S.l.] : [s.n.], 2001 - Tekst. - Proefschrift Universiteit Utrecht
- ^ Acacio BD, Stanczyk FZ, Mullin P, Saadat P, Jafarian N, Sokol RZ. Pharmacokinetics of dehydroepiandrosterone and its metabolites after long-term daily oral administration to healthy young men. Fertil Steril. Mar;81(3):595-604, 2004
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