Karboksipeptidaza C
| Karboksipeptidaza C | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.4.16.5 | ||||||||
| CAS broj | 9046-67-7 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Karboksipeptidaza C (EC 3.4.16.5, karboksipeptidaza Y, serinska karboksipeptidaza I, katepsin A, lizozomalni protektivni protein, deamidaza, lizozomalna karboksipeptidaza A, fazeolin) je enzim.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
- Odvajanje C-terminalne aminokiseline sa širokom specifičnošću
Ova karboksipeptidaza optimalno deluje na pH 4.5-6.0. Inhibira je diizopropil fluorofosfat, i senzitivna je na tiol-blokirajuće reagense.
Reference
[уреди | уреди извор]- ^ Breddam, K. (1986). „Serine carboxypeptidases. A review”. Carlsberg Res. Commun. 51: 83—128.
- ^ Valls, L.A., Hunter, C.P., Rothman, J.H. and Stevens, T.H. (1987). „Protein sorting in yeast: the localization determinant of yeast vacuolar carboxypeptidase Y resides in the propeptide”. Cell. 48: 887—897. PMID 3028649.
- ^ Jackman, H.L., Morris, P.W., Deddish, P.A., Skidgel, R.A. and Erdös, E.G. (1992). „Inactivation of endothelin I by deamidase (lysosomal protective protein)”. J. Biol. Chem. 267: 2872—2875. PMID 1737744.
- ^ Miller, J.J., Changaris, D.G. and Levy, R.S. (1992). „Purification, subunit structure and inhibitor profile of cathepsin-A”. J. Chromatogr. 627: 153—162. PMID 1487525.
Literatura
[уреди | уреди извор]- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
Spoljašnje veze
[уреди | уреди извор]- Carboxypeptidase+C на US National Library of Medicine Medical Subject Headings (MeSH)
| Digestivni enzimi | |
|---|---|
| Koagulacija |
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| Sistem komplementa |
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| Drugi, imunski sistem | |
| Venomi |
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| Drugi |
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| 3.4.11-19: Egzopeptidaza |
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|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 3.4.21-24: Endopeptidaza | Serinske peptidaze · Cisteinska proteaza · Aspartatna proteaza · Metaloendopeptidaze Druge/negrupisane: Sekretaza amiloidnog prekursornog proteina (Alfa-sekretaza, Beta-sekretaza 1, Beta-sekretaza 2, Gama sekretaza) | ||||||||||||||
| 3.4.99: Nepoznato | Stafilokinaza | ||||||||||||||
| Teme | |
|---|---|
| Tipovi | |
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