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Limfotoksin

Limfotoksin alfa
(TNF superfamilija, član 1)
Identifikatori
SimbolLTA
Alt. simboliTNFB
Entrez4049
HUGO6709
OMIM153440
RefSeqNM_000595
UniProtP01374
Ostali podaci
LokusHromozom 6 p21.3
Limfotoksin beta
(TNF superfamilija, član 3)
Identifikatori
SimbolLTB
Alt. simboliTNFC
Entrez4050
HUGO6711
OMIM600978
RefSeqNM_002341
UniProtQ06643
Ostali podaci
LokusHromozom 6 p21.3

Limfotoksin (takođe poznat kao faktor nekroze tumora-beta) je limfokin.[1] On je citokin koji proizvode "ubice" CD8+ T ćelije koje ubijaju viralno inficirane ćelije putem stvaranja otvora na njihovoj ćelijskoj membrani.[2][3]

Limfotoksin je homologan sa faktorom nekroze tumora alfa, ali ga luče T-ćelije. On je parakrin usled male proizvedene količine. Njegovi efekti su slični TNF-alfa efektima, mada je TNF-beta takođe važan za razvoj limfoidnih organa.

  1. ^ PD Crowe; TL VanArsdale; BN Walter; CF Ware; C Hession; B Ehrenfels; JL Browning; WS Din; RG Goodwin & CA Smith. „A lymphotoxin-beta-specific receptor”. Science. 264 (5159): 707—710. doi:10.1126/science.8171323. 
  2. ^ Kumaraguru U, Davis IA, Deshpande S, Tevethia SS, Rouse BT (2001). „Lymphotoxin alpha-/- mice develop functionally impaired CD8+ T cell responses and fail to contain virus infection of the central nervous system”. J Immunol. 166 (2): 1066—74. PMID 11145686. 
  3. ^ Mire-Sluis, Anthony R.; Thorpe, Robin, ур. (1998). Cytokines (Handbook of Immunopharmacology). Boston: Academic Press. ISBN 0-12-498340-5. 

Spoljašnje veze

[уреди | уреди извор]
  • Lymphotoxin на US National Library of Medicine Medical Subject Headings (MeSH)
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Limfotoksin
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