For faster navigation, this Iframe is preloading the Wikiwand page for Chloride potassium symporter.

Chloride potassium symporter

The chloride potassium symporter is a membrane transport protein of the solute carrier family 12 that is present in the S3-segment of the renal proximal tubule[1] and in the neuron.[2] It functions in renal chloride reabsorption to transport chloride across the basolateral membrane.[1] Chloride potassium symporter can lower intracellular chloride concentrations below the electrochemical equilibrium potential.[2]

The concentrations of K+ and Cl ions are high inside the cell due to the activities of Na+/K+ ATPase and NKCC cotransporter, respectively. Hence, their net driving force acting on the K/Cl cotransporter favours the exit of both K+ and Cl from the cell.

Types

[edit]

Chloride potassium symporter are classified into:

Each is encoded by a separate gene of the solute carrier family 12, hence accounting for the numbers succeeding its name. For example, chloride potassium symporter 5, or KCC2, is expressed through the SLC12A5 gene. Notably, symporters prior to 4 in the same family are other types of ion pumps. SLC12A3, for instance, is the sodium-chloride symporter.

References

[edit]
  1. ^ a b Walter F., PhD. Boron (2005). Medical Physiology: A Cellular And Molecular Approaoch. Elsevier/Saunders. ISBN 1-4160-2328-3. Page 780
  2. ^ a b "Entrez Gene: SLC12A5 solute carrier family 12, (potassium-chloride transporter) member 5". Retrieved 28 August 2013.


{{bottomLinkPreText}} {{bottomLinkText}}
Chloride potassium symporter
Listen to this article

This browser is not supported by Wikiwand :(
Wikiwand requires a browser with modern capabilities in order to provide you with the best reading experience.
Please download and use one of the following browsers:

This article was just edited, click to reload
This article has been deleted on Wikipedia (Why?)

Back to homepage

Please click Add in the dialog above
Please click Allow in the top-left corner,
then click Install Now in the dialog
Please click Open in the download dialog,
then click Install
Please click the "Downloads" icon in the Safari toolbar, open the first download in the list,
then click Install
{{::$root.activation.text}}

Install Wikiwand

Install on Chrome Install on Firefox
Don't forget to rate us

Tell your friends about Wikiwand!

Gmail Facebook Twitter Link

Enjoying Wikiwand?

Tell your friends and spread the love:
Share on Gmail Share on Facebook Share on Twitter Share on Buffer

Our magic isn't perfect

You can help our automatic cover photo selection by reporting an unsuitable photo.

This photo is visually disturbing This photo is not a good choice

Thank you for helping!


Your input will affect cover photo selection, along with input from other users.

X

Get ready for Wikiwand 2.0 ๐ŸŽ‰! the new version arrives on September 1st! Don't want to wait?