ATP11B
Identifiers
Aliases	ATP11B, ATPIF, ATPIR, ATPase phospholipid transporting 11B (putative)
External IDs	OMIM: 605869; MGI: 1923545; HomoloGene: 32919; GeneCards: ATP11B; OMA:ATP11B - orthologs
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3q26.33 Start 182,793,503 bp[1] End 182,921,629 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3|3 B Start 35,808,255 bp[2] End 35,910,425 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Achilles tendon epithelium of colon bone marrow cells sperm gingival epithelium secondary oocyte Skeletal muscle tissue of rectus abdominis oral cavity tonsil germinal epithelium Top expressed in neural layer of retina granulocyte cumulus cell large intestine colon left colon epithelium of small intestine pyloric antrum blood jejunum More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding ion transmembrane transporter activity metal ion binding protein binding ATPase-coupled intramembrane lipid transporter activity hydrolase activity ATP binding magnesium ion binding Cellular component integral component of membrane recycling endosome endosome Golgi apparatus membrane plasma membrane nuclear inner membrane recycling endosome membrane early endosome endoplasmic reticulum azurophil granule membrane trans-Golgi network Biological process lipid transport aminophospholipid transport phospholipid transport ion transport ion transmembrane transport phospholipid translocation neutrophil degranulation transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 23200 76295 Ensembl ENSG00000058063 ENSMUSG00000037400 UniProt Q9Y2G3 Q6DFW5 RefSeq (mRNA) NM_014616 NM_029570 RefSeq (protein) NP_055431 NP_083846 Location (UCSC) Chr 3: 182.79 – 182.92 Mb Chr 3: 35.81 – 35.91 Mb PubMed search [3] [4]
Wikidata
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Probable phospholipid-transporting ATPase IF is an enzyme that in humans is encoded by the ATP11B gene.^[5][6][7]

Function

P-type ATPases, such as ATP11B, are phosphorylated in their intermediate state and drive uphill transport of ions across membranes. Several subfamilies of P-type ATPases have been identified. One subfamily transports heavy metal ions, such as Cu(2+) or Cd(2+). Another subfamily transports non-heavy metal ions, such as H(+), Na(+), K(+), or Ca(+). A third subfamily transports amphipaths, such as phosphatidylserine.^[7]