阴道上皮内瘤变
| 阴道上皮内瘤变 | |
|---|---|
| 类型 | 上皮瘤病變[*]、阴道疾病[*] |
| 分类和外部资源 | |
| ICD-9-CM | 233.31 |
阴道上皮内瘤变（英語：Vaginal intraepithelial neoplasia, VAIN），是组织学上的阴道发育不良变化而形成的一种癌前病变[1]。
病理学
[编辑]这种瘤变非常罕见，并在病理学上呈现无症状[2]。阴道上皮内瘤变可以通过帕帕尼科拉乌试验（Pap test）探测出异常细胞的存在[2]。
和宫颈上皮内瘤样病变一样，VAIN也包括三级阶段，VAIN一级、VAIN二级、VAIN三级[3]。在VAIN一级中，三分之一的阴道皮肤细胞为异常细胞；VAIN三级中，全部阴道皮肤细胞为异常细胞[3]。VAIN三级通常被视为原位癌，或者阴道癌0级[3]。
80%的阴道上皮内瘤变病例，都与感染一些类型的人乳头瘤病毒（高危类型）有关[4]。在性接触之前注射过人类乳突病毒疫苗的女性，患阴道上皮内瘤变的概率会减少[5]。
一项研究发现阴道上皮内瘤变大多病发于阴道的上三分之一处，并呈现为多病灶状[6]；65%的VAIN患者同时患有宫颈上皮内瘤样病变，10%的VAIN患者同时患有外阴上皮内瘤变[6]。另外一项研究表明，大多数VAIN患者在单纯治疗后即能进入痊愈期，但是5%的案例恶化为更严重情况[7]。
参考
[编辑]- ^ Rapini, Ronald P.; Bolognia, Jean L.; Jorizzo, Joseph L. Dermatology: 2-Volume Set. St. Louis: Mosby. 2007: 1192. ISBN 1-4160-2999-0.
- ^ 2.0 2.1 Diakomanolis, E; Stefanidis, K; Rodolakis, A; Haidopoulos, D; Sindos, M; Chatzipappas, I; Michalas, S. Vaginal intraepithelial neoplasia: report of 102 cases.. European journal of gynaecological oncology. 2002, 23 (5): 457–9. PMID 12440826.
- ^ 3.0 3.1 3.2 Cancer Research UK (2002). The stages of cancer of the vagina 互联网档案馆的存檔，存档日期2007-10-07.. CancerHelp UK. Retrieved January 3, 2008.
- ^ Cancer Research UK (2002). Risks and causes of vaginal cancer 互联网档案馆的存檔，存档日期2007-10-07.. CancerHelp UK. Retrieved January 3, 2008.
- ^ FDA Approves Expanded Uses for Gardasil to Include Preventing Certain Vulvar and Vaginal Cancers. 2008-09-12 [2010-02-13]. （原始内容存档于2010-03-06）.
- ^ 6.0 6.1 Dodge, JA; Eltabbakh, GH; Mount, SL; Walker, RP; Morgan, A. Clinical features and risk of recurrence among patients with vaginal intraepithelial neoplasia.. Gynecologic oncology. 2001, 83 (2): 363–9. PMID 11606098. doi:10.1006/gyno.2001.6401.
- ^ Sillman, FH; Fruchter, RG; Chen, YS; Camilien, L; Sedlis, A; McTigue, E. Vaginal intraepithelial neoplasia: risk factors for persistence, recurrence, and invasion and its management.. American journal of obstetrics and gynecology. 1997, 176 (1 Pt 1): 93–9. PMID 9024096. doi:10.1016/S0002-9378(97)80018-X.
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