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西莫沙酮

西莫沙酮
臨床資料
ATC碼
  • 未分配
识别信息
  • 3-[[4-[5-(methoxymethyl)-2-oxo-oxazolidin-3-yl]phenoxy]methyl]benzonitrile
CAS号73815-11-9  checkY
PubChem CID
ChemSpider
UNII
KEGG
ChEMBL
CompTox Dashboard英语CompTox Chemicals Dashboard (EPA)
ECHA InfoCard100.070.537 編輯維基數據鏈接
化学信息
化学式C19H18N2O4
摩尔质量338.36 g·mol−1
  • InChI=1S/C19H18N2O4/c1-23-13-18-11-21(19(22)25-18)16-5-7-17(8-6-16)24-12-15-4-2-3-14(9-15)10-20/h2-9,18H,11-13H2,1H3 checkY
  • Key:MVVJINIUPYKZHR-UHFFFAOYSA-N checkY

西莫沙酮INN:cimoxatone;开发代号:MD 780515)是一种可逆性A型单胺氧化酶抑制剂[1]当它与酪胺联合使用时,会产生显著的食物相互作用相关的不良反应。[2]

合成

[编辑]
合成:[3]专利:[4]

参见

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参考资料

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  1. ^ Nair NP, Ahmed SK, Kin NM, West TE. Reversible and selective inhibitors of monoamine oxidase A in the treatment of depressed elderly patients. Acta Psychiatr Scand Suppl. 1995, 386: 28–35. PMID 7717092. S2CID 9100689. doi:10.1111/j.1600-0447.1995.tb05921.x. 
  2. ^ Nair NP, Ahmed SK, Kin NM. Biochemistry and pharmacology of reversible inhibitors of MAO-A agents: focus on moclobemide. J Psychiatry Neurosci. November 1993, 18 (5): 214–25. PMC 1188542可免费查阅. PMID 7905288. 
  3. ^ Ancher, J.F.; Cimoxatone. Drugs Fut 1984, 9, 6, 412.
  4. ^ DE2923295 idem Guy R. Bourgery et al. 美國專利第4,287,351号 (1981 to Delalande S.A.). See for compound 200.
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西莫沙酮
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