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白三烯E4

白三烯E4
系统名
(5S,6R,7E,9E,11Z,14Z)-6-(2-amino-2-carboxyethyl)sulfanyl-5-hydroxyicosa-7,9,11,14-tetraenoic acid
识别
缩写 LTE4
CAS号 75715-89-8  ☒N
PubChem 5280749
ChemSpider 4444402 checkY
SMILES
 
  • CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)O)N
InChI
 
  • 1S/C23H37NO5S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-21(30-18-19(24)23(28)29)20(25)15-14-17-22(26)27/h6-7,9-13,16,19-21,25H,2-5,8,14-15,17-18,24H2,1H3,(H,26,27)(H,28,29)/b7-6-,10-9-,12-11+,16-13+/t19?,20-,21+/m0/s1
InChIKey OTZRAYGBFWZKMX-MPWKMEBCSA-N
ChEBI 15650
KEGG C05952
MeSH Leukotriene+E4
性质
化学式 C23H37NO5S
摩尔质量 439.61 g·mol−1
若非注明,所有数据均出自标准状态(25 ℃,100 kPa)下。

白三烯E4(英語:Leukotriene E4)是一种与炎症反应有关的半胱氨酰白三烯类物质,由几种白细胞产生,包括嗜酸性粒細胞肥大细胞巨噬细胞嗜碱性粒细胞,最近还发现了有血小板粘附的中性粒细胞也能产生白三烯E4[1]

类二十烷酸的合成(右侧为白三烯)

参考文献

[编辑]
  1. ^ Laidlaw TM, Kidder MS, Bhattacharyya N, Xing W, Shen S, Milne GL, Castells MC, Chhay H, Boyce JA. Cysteinyl leukotriene overproduction in aspirin exacerbated respiratory disease is driven by platelet-adherent leukocytes. Blood. 2012, 119 (16): 3790–3798. PMC 3335383可免费查阅. PMID 22262771. doi:10.1182/blood-2011-10-384826. 
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白三烯E4
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