顺乌头酸酶
| 乌头酸水合酶 | |||||||
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| 结合铁-硫簇的猪顺乌头酸酶插画。按二级结构将蛋白质着色，铁原子以蓝色表示，硫原子以红色表示[1]。 | |||||||
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| 识别码 | |||||||
| EC編號 | 4.2.1.3 | ||||||
| CAS号 | 9024-25-3 | ||||||
| 数据库 | |||||||
| IntEnz | IntEnz浏览 | ||||||
| BRENDA | BRENDA入口 | ||||||
| ExPASy | NiceZyme浏览 | ||||||
| KEGG | KEGG入口 | ||||||
| MetaCyc | 代谢路径 | ||||||
| PRIAM | 概述 | ||||||
| PDB | RCSB PDB PDBj PDBe PDBsum | ||||||
| 基因本体 | AmiGO / EGO | ||||||
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| 顺乌头酸酶家族 （乌头酸水合酶） | |||||||||
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 顺乌头酸酶结构[2]。 | |||||||||
| 鑑定 | |||||||||
| 標誌 | 顺乌头酸酶 | ||||||||
| Pfam | PF00330（旧版） | ||||||||
| InterPro | IPR001030 | ||||||||
| PROSITE | PDOC00423 | ||||||||
| SCOP | 1aco / SUPFAM | ||||||||
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顺乌头酸酶[3]（英語：aconitase，简称为乌头酸酶，EC 4.2.1.3）是一种在三羧酸循环中催化柠檬酸通过顺乌头酸中间步骤立体专一性可逆异构化为异柠檬酸的酶，这是一个非氧化还原步骤[4][5][6]。
家族成员
[编辑]从细菌到人类，顺乌头酸酶都可以被表达出来。人类表达以下两种同工酶：
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参考文献
[编辑]- ^ PDB 7ACN; Lauble, H.; Kennedy, M. C.; Beinert, H.; Stout, C. D. Crystal structures of aconitase with isocitrate and nitroisocitrate bound. Biochemistry. 1992, 31 (10): 2735–48. PMID 1547214. doi:10.1021/bi00125a014.
- ^ PDB 1ACO; Lauble, H; Kennedy, MC; Beinert, H; Stout, CD. Crystal Structures of Aconitase with Trans-aconitate and Nitrocitrate Bound. Journal of Molecular Biology. 1994, 237 (4): 437–51. PMID 8151704. doi:10.1006/jmbi.1994.1246.
- ^ [1][永久失效連結]
- ^ Beinert, H; Kennedy, MC. Aconitase, a two-faced protein: Enzyme and iron regulatory factor. The FASEB journal. 1993, 7 (15): 1442–9. PMID 8262329.
- ^ Flint, Dennis H.; Allen, Ronda M. Iron−Sulfur Proteins with Nonredox Functions. Chemical Reviews. 1996, 96 (7): 2315–34. doi:10.1021/cr950041r.
- ^ Beinert, Helmut; Kennedy, Mary Claire; Stout, C. David. Aconitase as Iron−Sulfur Protein, Enzyme, and Iron-Regulatory Protein. Chemical Reviews. 1996, 96 (7): 2335–74. doi:10.1021/cr950040z.
深入阅读
[编辑]- Frishman, Dmitrij; Hentze, Matthias W. Conservation of Aconitase Residues Revealed by Multiple Sequence Analysis. Implications for Structure/Function Relationships. European Journal of Biochemistry. 1996, 239 (1): 197–200. PMID 8706708. doi:10.1111/j.1432-1033.1996.0197u.x.
外部链接
[编辑]- 醫學主題詞表（MeSH）：Aconitase
- Proteopedia Aconitase - the Aconitase structure in interactive 3D
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