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MYO1E

MYO1E
已知的结构
PDB直系同源搜索: PDBe RCSB
识别号
别名MYO1E;, FSGS6, HuncM-IC, MYO1C, myosin IE
外部IDOMIM601479 MGI106621 HomoloGene:55864 GeneCardsMYO1E
相关疾病
focal segmental glomerulosclerosis 6、​局部性肾小球硬化症[1]
基因位置(人类
15号染色体
染色体15号染色体[2]
15号染色体
MYO1E的基因位置
MYO1E的基因位置
基因座15q22.2起始59,132,434 bp[2]
终止59,372,871 bp[2]
RNA表达模式
查阅更多表达数据
直系同源
物种人类小鼠
Entrez
Ensembl
UniProt
mRNA​序列

NM_004998

NM_181072
​NM_025612

蛋白序列

NP_004989

NP_851417

基因位置​(UCSC)Chr 15: 59.13 – 59.37 MbChr 9: 70.11 – 70.31 Mb
PubMed​查找[4][5]
维基数据
查看/编辑人类查看/编辑小鼠

MYO1E是一个位于人类15号染色体上的基因,编码一种隶属肌凝蛋白超家族的蛋白肌凝蛋白-Ie(Myosin-Ie)。MYO1E编码的肌凝蛋白-Ie是一种非典型的肌凝蛋白,与编码肌凝蛋白-1的MYH1是两种不同的基因[6][7][8]

MYO1E编码的肌凝蛋白-Ie由一个靠近N端的动力结构域、一个IQ模体、一个含有一个PH结构域的TH1结构域、一个富含脯氨酸的TH2结构域,以及一个SH3结构域组成[9]

参见

[编辑]

参考资料

[编辑]
  1. ^ 與MYO1E相關的疾病;在維基數據上查看/編輯參考. 
  2. ^ 2.0 2.1 2.2 GRCh38: Ensembl release 89: ENSG00000157483 - Ensembl, May 2017
  3. ^ 3.0 3.1 3.2 GRCm38: Ensembl release 89: ENSMUSG00000032220 - Ensembl, May 2017
  4. ^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine. 
  5. ^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine. 
  6. ^ MYO1E Gene. GeneCards. [2021-05-02]. (原始内容存档于2021-06-04). 
  7. ^ Hasson T, Skowron JF, Gilbert DJ, Avraham KB, Perry WL, Bement WM, et al. Mapping of unconventional myosins in mouse and human. Genomics. September 1996, 36 (3): 431–9. PMID 8884266. doi:10.1006/geno.1996.0488. 
  8. ^ Entrez Gene: MYO1E myosin IE. [2021-05-02]. (原始内容存档于2010-12-05). 
  9. ^ McConnell RE, Tyska MJ. Leveraging the membrane - cytoskeleton interface with myosin-1. Trends in Cell Biology. July 2010, 20 (7): 418–26. PMC 2897960可免费查阅. PMID 20471271. doi:10.1016/j.tcb.2010.04.004 (英语). 
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MYO1E
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